Isocyanide (isonitrile) chemistry began in 1859 when Lieke obtained the first compound of
this type. 1 In 1958, isocyanides became generally available by dehydration of formamides …

Proteinogenic and non-proteinogenic R-amino acids (R-AAs) constitute one of the five most
important families of natural products1 and are essential molecules in many scientific areas …

Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically
accepted treatment to cure or halt its progression. The worldwide effort to develop peptide …

The importance of aromatic structures in organic chemistry can never be underestimated.
Nature uses compounds containing aromatic or heteroaromatic nuclei extensively as the …

Recent progress on the stereoselective synthesis of acyclic quaternary α-amino acids -
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Abstract The [2+ 2+ 2] cycloaddition strategy is complementary to the well known Diels–
Alder reaction for the generation of polycyclic compounds. This [2+ 2+ 2] approach is atom …

CuBr2-catalyzed three-component coupling of N-benzylallylamine, ethyl glyoxalate, and
terminal alkynes afforded glycine-tethered 1, 6-enynes, which were further transformed into …

In this account we disclose a variety of simple strategies demonstrated in our laboratory in
the last two decades for the assembly of diverse and intricate molecular frameworks …

Here we describe several useful strategies to a variety of unusual α-amino acid derivatives
and peptides based on “building block” approach. These building blocks are suitable for …

Polycyclic aromatic hydrocarbons (PAHs) play an important role in different areas of organic
chemistry (eg, organic electro-active materials, chiral helicenes), and biochemistry …