Q fever immunology: the quest for a safe and effective vaccine

G Sam, J Stenos, SR Graves, BHA Rehm - npj Vaccines, 2023 - nature.com
Q fever is an infectious zoonotic disease, caused by the Gram-negative bacterium Coxiella
burnetii. Transmission occurs from livestock to humans through inhalation of a survival form …

Recent advances in genetic systems in obligate intracellular human-pathogenic bacteria

DJ Fisher, PA Beare - Frontiers in Cellular and Infection Microbiology, 2023 - frontiersin.org
The ability to genetically manipulate a pathogen is fundamental to discovering factors
governing host–pathogen interactions at the molecular level and is critical for devising …

A protein–protein interaction map reveals that the Coxiella burnetii effector CirB inhibits host proteasome activity

M Fu, Y Liu, G Wang, P Wang, J Zhang, C Chen… - PLoS …, 2022 - journals.plos.org
Coxiella burnetii is the etiological agent of the zoonotic disease Q fever, which is featured by
its ability to replicate in acid vacuoles resembling the lysosomal network. One key virulence …

Single-cell analysis of multiple invertible promoters reveals differential inversion rates as a strong determinant of bacterial population heterogeneity

F Lan, J Saba, Y Qian, T Ross, R Landick… - Science …, 2023 - science.org
Population heterogeneity can promote bacterial fitness in response to unpredictable
environmental conditions. A major mechanism of phenotypic variability in the human gut …

Coxiella burnetii inhibits host immunity by a protein phosphatase adapted from glycolysis

Y Zhang, J Fu, S Liu, L Wang, J Qiu… - Proceedings of the …, 2022 - National Acad Sciences
Coxiella burnetii is a bacterial pathogen that replicates within host cells by establishing a
membrane-bound niche called the Coxiella-containing vacuole. Biogenesis of this …

[HTML][HTML] Coxiella burnetii: international pathogen of mystery

AL Dragan, DE Voth - Microbes and infection, 2020 - Elsevier
Coxiella burnetii is an intracellular bacterium that causes acute and chronic Q fever. This
unique pathogen has been historically challenging to study due to obstacles in genetically …

Seropositivity for Coxiella burnetii in Wild Boar (Sus scrofa) and Red Deer (Cervus elaphus) in Portugal

H Pires, L Cardoso, AP Lopes, MC Fontes, M Matos… - Pathogens, 2023 - mdpi.com
Q fever is caused by the pathogen Coxiella burnetii and is a zoonosis that naturally infects
goats, sheep, and cats, but can also infect humans, birds, reptiles, or arthropods. A survey …

Q fever vaccine development: current strategies and future considerations

CM Long - Pathogens, 2021 - mdpi.com
Q fever is a zoonotic disease caused by the intracellular pathogen Coxiella burnetii. This
disease typically manifests as a self-limiting, febrile illness known as acute Q fever. Due to …

Comparative virulence of diverse Coxiella burnetii strains

CM Long, PA Beare, DC Cockrell, CL Larson… - Virulence, 2019 - Taylor & Francis
Coxiella burnetii is an intracellular, gram-negative bacterium that causes the zoonosis Q
fever. This disease typically presents as an acute flu-like illness with persistent, focalized …

The Coxiella burnetii T4SS effector protein AnkG hijacks the 7SK small nuclear ribonucleoprotein complex for reprogramming host cell transcription

A Cordsmeier, S Rinkel, M Jeninga… - PLoS …, 2022 - journals.plos.org
Inhibition of host cell apoptosis is crucial for survival and replication of several intracellular
bacterial pathogens. To interfere with apoptotic pathways, some pathogens use specialized …