Applications of focused ultrasound in the brain: from thermoablation to drug delivery
Focused ultrasound (FUS) is a disruptive medical technology, and its implementation in the
clinic represents the culmination of decades of research. Lying at the convergence of …
clinic represents the culmination of decades of research. Lying at the convergence of …
[HTML][HTML] Ultrasound-responsive cavitation nuclei for therapy and drug delivery
K Kooiman, S Roovers, SAG Langeveld… - Ultrasound in medicine …, 2020 - Elsevier
Therapeutic ultrasound strategies that harness the mechanical activity of cavitation nuclei for
beneficial tissue bio-effects are actively under development. The mechanical oscillations of …
beneficial tissue bio-effects are actively under development. The mechanical oscillations of …
Blood-brain barrier opening in primary brain tumors with non-invasive MR-guided focused ultrasound: a clinical safety and feasibility study
T Mainprize, N Lipsman, Y Huang, Y Meng… - Scientific reports, 2019 - nature.com
The blood-brain barrier (BBB) has long limited therapeutic access to brain tumor and
peritumoral tissue. In animals, MR-guided focused ultrasound (MRgFUS) with intravenously …
peritumoral tissue. In animals, MR-guided focused ultrasound (MRgFUS) with intravenously …
Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery
Apart from its clinical use in imaging, ultrasound has been thoroughly investigated as a tool
to enhance drug delivery in a wide variety of applications. Therapeutic ultrasound, as such …
to enhance drug delivery in a wide variety of applications. Therapeutic ultrasound, as such …
The role of ultrasound-driven microbubble dynamics in drug delivery: from microbubble fundamentals to clinical translation
In the last couple of decades, ultrasound-driven microbubbles have proven excellent
candidates for local drug delivery applications. Besides being useful drug carriers …
candidates for local drug delivery applications. Besides being useful drug carriers …
Theranostic strategy of focused ultrasound induced blood-brain barrier opening for CNS disease treatment
Focused Ultrasound (FUS) in combination with gaseous microbubbles has emerged as a
potential new means of effective drug delivery to the brain. Recent research has shown that …
potential new means of effective drug delivery to the brain. Recent research has shown that …
Central nervous system delivery of molecules across the blood-brain barrier
Therapies targeting neurological conditions such as Alzheimer's or Parkinson's diseases are
hampered by the presence of the blood-brain barrier (BBB). During the last decades, several …
hampered by the presence of the blood-brain barrier (BBB). During the last decades, several …
[HTML][HTML] State-of-the-art of microbubble-assisted blood-brain barrier disruption
Focused ultrasound with microbubbles promises unprecedented advantages for blood-brain
barrier disruption over existing intracranial drug delivery methods, as well as a significant …
barrier disruption over existing intracranial drug delivery methods, as well as a significant …
Safety and efficacy of focused ultrasound induced blood-brain barrier opening, an integrative review of animal and human studies
Y Meng, CB Pople, H Lea-Banks, A Abrahao… - Journal of controlled …, 2019 - Elsevier
The blood-brain barrier, while fundamental in maintaining homeostasis in the central
nervous system, is a bottleneck to achieving efficacy for numerous therapeutics. Improved …
nervous system, is a bottleneck to achieving efficacy for numerous therapeutics. Improved …
[HTML][HTML] Efficacy of gene delivery to the brain using AAV and ultrasound depends on serotypes and brain areas
Focused ultrasound combined with intravenously injected microbubbles (FUS) is known to
non-invasively, locally, and transiently increase the permeability of the blood-brain barrier …
non-invasively, locally, and transiently increase the permeability of the blood-brain barrier …