Bispecific antibodies have recently attracted intense interest. CrossMab technology was
described in 2011 as novel approach enabling correct antibody light-chain association with …

Effective delivery of protein therapeutics to the central nervous system (CNS) has been
greatly restricted by the blood-brain barrier (BBB). We describe the development of a BBB …

Development of cancers mostly involves more than one signal pathways, because of the
complicated nature of cancer cells. As such, the most effective treatment option is the one …

African swine fever virus (ASFV) infects domestic pigs and European wild boars with strong,
hemorrhagic and high mortality. The primary cellular targets of ASFV is the porcine …

Inhibition of complement activation via the overexpression of complement-regulatory
proteins (CRPs), most notably CD46, CD55 and CD59, is an efficient mechanism of disguise …

Bispecific antibodies and antibody fragments are therapeutics of growing importance. They
are clinically applied for effector cell engagement, enhanced targeting selectivity …

Abstract Antigen-binding Fc (Fcab™) fragments, where a novel antigen binding site is
introduced by the mutagenesis of the C-terminal loops of the CH3 domain, function as parts …

Background: Monoclonal antibodies have been proven to deliver significant contribution in
health industry for the development of both therapeutics and diagnostics. Efforts have been …

The overexpression of tyrosine kinase HER2 in numerous cancers, connected with fierce
signaling and uncontrolled proliferation, makes it a suitable target for immunotherapy. The …

Thermostability is considered a crucial parameter to evaluate the viability of enzymes in
industrial applications. Over the past 31 years, many studies have been reported on the …