Neuro-toxic and reproductive effects of BPA

A Santoro, R Chianese, J Troisi… - Current …, 2019 - ingentaconnect.com
Background: Bisphenol A (BPA) is one of the highest volume chemicals produced
worldwide. It has recognized activity as an endocrine-disrupting chemical and has …

A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

JL Blankman, GM Simon, BF Cravatt - Chemistry & biology, 2007 - cell.com
Endogenous ligands for cannabinoid receptors (" endocannabinoids") include the lipid
transmitters anandamide and 2-arachidonoylglycerol (2-AG). Endocannabinoids modulate a …

Obesity: Current and potential pharmacotherapeutics and targets

V Narayanaswami, LP Dwoskin - Pharmacology & therapeutics, 2017 - Elsevier
Obesity is a global epidemic that contributes to a number of health complications including
cardiovascular disease, type 2 diabetes, cancer and neuropsychiatric disorders …

Drug treatments for obesity: orlistat, sibutramine, and rimonabant

RS Padwal, SR Majumdar - The Lancet, 2007 - thelancet.com
Antiobesity treatment is recommended for selected patients in whom lifestyle modification is
unsuccessful. Two antiobesity drugs are currently licensed for long-term use. Orlistat, a …

Chemical probes of endocannabinoid metabolism

JL Blankman, BF Cravatt, EL Barker - Pharmacological reviews, 2013 - Elsevier
The endocannabinoid signaling system regulates diverse physiologic processes and has
attracted considerable attention as a potential pharmaceutical target for treating diseases …

Enzymatic pathways that regulate endocannabinoid signaling in the nervous system

K Ahn, MK McKinney, BF Cravatt - Chemical reviews, 2008 - ACS Publications
Chemical signals, or neurotransmitters, represent the fundamental mode for intercellular
communication in the nervous system. 1 The classical model for neurotransmitter action …

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo

JZ Long, DK Nomura, RE Vann… - Proceedings of the …, 2009 - National Acad Sciences
Δ9-Tetrahydrocannabinol (THC), the psychoactive component of marijuana, and other direct
cannabinoid receptor (CB1) agonists produce a number of neurobehavioral effects in …

A biosynthetic pathway for anandamide

J Liu, L Wang, J Harvey-White… - Proceedings of the …, 2006 - National Acad Sciences
The endocannabinoid arachidonoyl ethanolamine (anandamide) is a lipid transmitter
synthesized and released “on demand” by neurons in the brain. Anandamide is also …

Endocannabinoids and the control of energy balance

I Matias, V Di Marzo - Trends in Endocrinology & Metabolism, 2007 - cell.com
Two receptors have been cloned to date for the psychotropic compound Δ 9-
tetrahydrocannabinol, and termed cannabinoid CB 1 and CB 2 receptors. Their endogenous …

Impact of dietary fats on brain functions

R Chianese, R Coccurello, A Viggiano… - Current …, 2018 - ingentaconnect.com
Background: Adequate dietary intake and nutritional status have important effects on brain
functions and on brain health. Energy intake and specific nutrients excess or deficiency from …