Endogenous ligands for cannabinoid receptors (" endocannabinoids") include the lipid transmitters anandamide and 2-arachidonoylglycerol (2-AG). Endocannabinoids modulate a …
Obesity is a global epidemic that contributes to a number of health complications including cardiovascular disease, type 2 diabetes, cancer and neuropsychiatric disorders …
RS Padwal, SR Majumdar - The Lancet, 2007 - thelancet.com
Antiobesity treatment is recommended for selected patients in whom lifestyle modification is unsuccessful. Two antiobesity drugs are currently licensed for long-term use. Orlistat, a …
The endocannabinoid signaling system regulates diverse physiologic processes and has attracted considerable attention as a potential pharmaceutical target for treating diseases …
K Ahn, MK McKinney, BF Cravatt - Chemical reviews, 2008 - ACS Publications
Chemical signals, or neurotransmitters, represent the fundamental mode for intercellular communication in the nervous system. 1 The classical model for neurotransmitter action …
JZ Long, DK Nomura, RE Vann… - Proceedings of the …, 2009 - National Acad Sciences
Δ9-Tetrahydrocannabinol (THC), the psychoactive component of marijuana, and other direct cannabinoid receptor (CB1) agonists produce a number of neurobehavioral effects in …
J Liu, L Wang, J Harvey-White… - Proceedings of the …, 2006 - National Acad Sciences
The endocannabinoid arachidonoyl ethanolamine (anandamide) is a lipid transmitter synthesized and released “on demand” by neurons in the brain. Anandamide is also …
I Matias, V Di Marzo - Trends in Endocrinology & Metabolism, 2007 - cell.com
Two receptors have been cloned to date for the psychotropic compound Δ 9- tetrahydrocannabinol, and termed cannabinoid CB 1 and CB 2 receptors. Their endogenous …
R Chianese, R Coccurello, A Viggiano… - Current …, 2018 - ingentaconnect.com
Background: Adequate dietary intake and nutritional status have important effects on brain functions and on brain health. Energy intake and specific nutrients excess or deficiency from …