Melatonin receptors are seven transmembrane‐spanning proteins belonging to the GPCR
superfamily. In mammals, two melatonin receptor subtypes exist‐MT1 and MT2‐encoded by …

The pineal hormone melatonin regulates seasonal reproductive function and modulates
circadian rhythms in mammals. We now report the cloning and characterization of a high …

AG protein-coupled receptor for the pineal hormone melatonin was recently cloned from
mammals and designated the Mel1a melatonin receptor. We now report the cloning of a …

Page 1 Melatonin and the Mammalian Pineal Gland Josephine Arendt CHAPMAN & HALL
Page 2 Page 3 54331LVSX00373 Qty: 1 Melatonin and the Mammalian Pineal Page 4 Page 5 …

Vanecek, Jiri. Cellular Mechanisms of Melatonin Action. Physiol. Rev. 78: 687–721, 1998.—
The pineal hormone melatonin is involved in photic regulations of various kinds, including …

Introduction 3. Melatonin receptors 3.1. MT1 and MT2 melatonin receptors 3.1. 1. Molecular
structure 3.1. 2. Pharmacology 3.1. 2.1. Efficacy, potency and affinity 3.1. 2.2. Ligand …

A pre-requisite to understanding the physiological mechanisms of action of melatonin is the
identification of the target sites where the hormone acts. The radioligand 2-[125 I] …

Melatonin receptors (MT1 and MT2 in humans) are family AG protein–coupled receptors that
respond to the neurohormone melatonin to regulate circadian rhythm and sleep. Numerous …

Using an expression cloning strategy, a high-affinity melatonin receptor cDNA has been
isolated from Xenopus laevis dermal melanophores. Transient expression of the cDNA in …

The pineal hormone, melatonin, is an important regulator of seasonal reproduction and
circadian rhythms. Its effects are mediated via high-affinity melatonin receptors, located on …