During placentation invasive extravillous trophoblasts (EVTs) migrate into the maternal
uterus and modify its vessels. In particular, remodeling of the spiral arteries by EVTs is …

Implantation failure and inadequate placental development are important contributors to
infertility, recurrent miscarriage, and other pregnancy-related problems in women. Better …

Invading human leukocyte antigen-G+ (HLA‐G+) extravillous trophoblasts (EVT) are rare
cells that are believed to play a key role in the prevention of a maternal immune attack on …

Carcinomas, cancers of epithelial origin, constitute the majority of all cancers. Loss of
epithelial characteristics is an early step in carcinoma progression. Malignant transformation …

Critical roles for DNA methylation in embryonic development are well established, but less is
known about its roles during trophoblast development, the extraembryonic lineage that gives …

The pregnancy-specific glycoproteins (PSGs) are the most abundant trophoblastic proteins
in maternal blood during human pregnancy and they appear to be exclusive to species with …

The hemochorial placenta develops from the coordinated multilineage differentiation of
trophoblast stem (TS) cells. An invasive trophoblast cell lineage remodels uterine spiral …

The human placenta contains two specialized regions: the villous chorion where gases and
nutrients are exchanged between maternal and fetal blood, and the smooth chorion (SC) …

Proper differentiation of trophoblast cells in the human placenta is a prerequisite for a
successful pregnancy, and dysregulation of this process may lead to malignant pregnancy …

During pregnancy, invading HLA-G+ extravillous trophoblasts (EVT) play a key role in
placental development, uterine spiral artery remodeling, and prevention of detrimental …