SUMMARY HIV-1 DNA persists in infected cells despite combined antiretroviral therapy
(cART), forming viral reservoirs. Recent trials of strategies targeting latent HIV reservoirs …

Integration of viral DNA into the host genome is a central event in the replication cycle and
the pathogenesis of retroviruses, including HIV. Although most cells infected with HIV are …

The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host
characteristics associated with reservoir size and long-term dynamics in 1,057 individuals …

Viral rebound upon stopping combined antiretroviral therapy poses a major barrier toward
an HIV cure. Cellular and anatomical sources responsible for reinitiating viral replication …

HIV DNA is a marker of HIV persistence that predicts HIV progression and remission, but its
kinetics in early acute HIV infection (AHI) is poorly understood. We longitudinally measured …

HIV cure efforts are hampered by limited characterization of the cells supporting HIV
replication in vivo and inadequate methods for quantifying the latent viral reservoir in …

Summary HIV-1 infection of CD4+ T cells leads to cytopathic effects and cell demise, which
is counter to the observation that certain HIV-1-infected cells possess a remarkable long …

Disease-free infection in HIV-infected adults is associated with human leukocyte antigen–
mediated suppression of viremia, whereas in the sooty mangabey and other healthy natural …

Cells that actively transcribe HIV-1 have been defined as the “active viral reservoir” in HIV-
infected individuals. However, important technical limitations have precluded the …

Summary Schlafen 11 (SLFN11) was recently discovered as a cellular restriction factor
against replication stress. Here, we show that SLFN11 increases chromatin accessibility …