Microtubules are cylindrical protein polymers formed from α β-tubulin heterodimers in the
cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the …

Due to the three domains of the colchicine-site which is conducive to the combination with
small molecule compounds, colchicine-site on the tubulin has become a common target for …

A series of mono-and bis-1, 2, 3-triazole-based molecular architectures were prepared in
excellent yields via the standard copper (I)-catalysed azide–alkyne cycloaddition (CuAAC) …

A general metal-free route to 1, 4-disubstituted and 1, 4, 5-trisubstituted 1, 2, 3-triazoles was
developed. α-Haloacroleins reacted with organic azides in a DMSO/H2O mixture solvent at …

Cancer is the most lethal disease that may be found anywhere globally. Approximately 10%
of individuals die due to cancer of various types, with 19.3 million new cancer cases and 10 …

Tubulin, as the fundamental unit of microtubules, is a crucial target in the investigation of
anticarcinogens. The synthesis and assessment of small-molecule tubulin polymerization …

Abstract A series of 2-aryl-4-(3, 4, 5-trimethoxybenzoyl)-5-substituted-1, 2, 3-triazoles were
designed, synthesized and evaluated for the anticancer activities. Based on the model of …

Abstract A series of 1-aryl-5-(4-arylpiperazine-1-carbonyl)-1 H-tetrazols as microtubule
destabilizers were designed, synthesised and evaluated for anticancer activity. Based on …

This manuscript unveils the synthesis of 2H-thiazolo [4, 5-d][1, 2, 3] triazole (ThTz), an
unprecedented [5-5]-fused heteroaromatic system, and established a scalable synthetic …

Microtubules are a validated clinical target for the treatment of many cancers. We describe
the design, synthesis, biochemical evaluation, and molecular modelling studies of a series …