Engineered bacteriophage therapeutics: rationale, challenges and future

M Łobocka, K Dąbrowska, A Górski - BioDrugs, 2021 - Springer
The current problems with increasing bacterial resistance to antibacterial therapies, resulting
in a growing frequency of incurable bacterial infections, necessitates the acceleration of …

Molecular genetics of mycobacteriophages

GF Hatfull - Molecular genetics of mycobacteria, 2014 - Wiley Online Library
Mycobacteriophages are viruses that infect mycobacterial hosts including Mycobacterium
smegmatis and Mycobacterium tuberculosis. The first mycobacteriophages were isolated in …

Synthetic engineering and biological containment of bacteriophages

S Mitsunaka, K Yamazaki… - Proceedings of the …, 2022 - National Acad Sciences
The serious threats posed by drug-resistant bacterial infections and recent developments in
synthetic biology have fueled a growing interest in genetically engineered phages with …

CRISPR-Cas: an efficient tool for genome engineering of virulent bacteriophages

B Martel, S Moineau - Nucleic acids research, 2014 - academic.oup.com
Bacteriophages are now widely recognized as major players in a wide variety of
ecosystems. Novel genes are often identified in newly isolated phages as well as in …

[图书][B] Molecular genetics of mycobacteria

GF Hatfull, WR Jacobs Jr - 2020 - books.google.com
A comprehensive collection of perspectives by experts in mycobacterial molecular biology
Mycobacterium tuberculosis causes one in four avoidable deaths in the developing world …

Engineered K1F bacteriophages kill intracellular Escherichia coli K1 in human epithelial cells

C Møller-Olsen, SFS Ho, RD Shukla, T Feher… - Scientific reports, 2018 - nature.com
Bacterial infections can be treated with bacteriophages that show great specificity towards
their bacterial host and can be genetically modified for different applications. However …

Approaches to optimize therapeutic bacteriophage and bacteriophage-derived products to combat bacterial infections

M Reuter, DH Kruger - Virus Genes, 2020 - Springer
The emerging occurrence of antibiotic-resistant bacterial pathogens leads to a recollection
of bacteriophage as antimicrobial therapeutics. This article presents a short overview of the …

Activity of Bacteriophage D29 Loaded on Nanoliposomes against Macrophages Infected with Mycobacterium tuberculosis

APB Silva, CA Roque-Borda, CS Carnero Canales… - Diseases, 2023 - mdpi.com
The search for new antimicrobial agents is a continuous struggle, mainly because more and
more cases of resistant strains are being reported. Mycobacterium tuberculosis (MTB) is the …

Genetic engineering and biosynthesis technology: Keys to unlocking the chains of phage therapy

S Lv, Y Wang, K Jiang, X Guo, J Zhang, F Zhou, Q Li… - Viruses, 2023 - mdpi.com
Phages possess the ability to selectively eliminate pathogenic bacteria by recognizing
bacterial surface receptors. Since their discovery, phages have been recognized for their …

Phage-based detection of bacterial pathogens

RG Van der Merwe, PD Van Helden, RM Warren… - Analyst, 2014 - pubs.rsc.org
Bacterial pathogens cause significant morbidity and mortality annually to both humans and
animals. With the rampant spread of drug resistance and the diminishing effectiveness of …