Drug delivery approaches for enhanced antibiofilm therapy

T Wang, EJ Cornel, C Li, J Du - Journal of Controlled Release, 2023 - Elsevier
Biofilms have attracted increasing attention in recent years. Many bacterial infections are
associated with biofilm formation. A bacterial biofilm is an aggregated membrane-like …

The road ahead to successful BBB opening and drug-delivery with focused ultrasound

M López-Aguirre, M Castillo-Ortiz… - Journal of Controlled …, 2024 - Elsevier
This review delves into the innovative technology of Blood-Brain Barrier (BBB) opening with
low-intensity focused ultrasound in combination with microbubbles (LIFU-MB), a promising …

BBB opening with focused ultrasound in nonhuman primates and Parkinson's disease patients: Targeted AAV vector delivery and PET imaging

J Blesa, JA Pineda-Pardo, K Inoue, C Gasca-Salas… - Science …, 2023 - science.org
Intracerebral vector delivery in nonhuman primates has been a major challenge. We report
successful blood-brain barrier opening and focal delivery of adeno-associated virus …

Natural aging and Alzheimer's disease pathology increase susceptibility to focused ultrasound-induced blood–brain barrier opening

RL Noel, AJ Batts, R Ji, AN Pouliopoulos, S Bae… - Scientific Reports, 2023 - nature.com
Focused Ultrasound (FUS) paired with systemically-injected microbubbles (μB) is capable of
transiently opening the blood–brain barrier (BBBO) for noninvasive and targeted drug …

Elucidation of the mechanism of Yiqi Tongluo Granule against cerebral ischemia/reperfusion injury based on a combined strategy of network pharmacology, multi …

Y Yuan, P Sheng, B Ma, B Xue, M Shen, L Zhang, D Li… - Phytomedicine, 2023 - Elsevier
Background Ischemic stroke is caused by local lesions of the central nervous system and is
a severe cerebrovascular disease. A traditional Chinese medicine, Yiqi Tongluo Granule …

Ultrasound-mediated piezoelectric nanoparticle modulation of intrinsic cardiac autonomic nervous system for rate control in atrial fibrillation

J Han, Y Zhang, X Wang, G Zhang, Z Yu, C Wang… - Biomaterials …, 2023 - pubs.rsc.org
Rate control is a cornerstone of atrial fibrillation treatment. Barium titanate nanoparticles
(BTNPs) are piezoelectric nanomaterials that can generate local electromagnetic fields …

In vitro modeling of the blood–brain barrier for the study of physiological conditions and Alzheimer's disease

TG Schreiner, I Creangă-Murariu, BI Tamba, N Lucanu… - Biomolecules, 2022 - mdpi.com
The blood–brain barrier (BBB) is an essential structure for the maintenance of brain
homeostasis. Alterations to the BBB are linked with a myriad of pathological conditions and …

Targeting non-coding RNA for CNS injuries: regulation of blood-brain barrier functions

L Zhang, W Bai, L Sun, Y Lin, M Tian - Neurochemical research, 2023 - Springer
Central nervous system (CNS) injuries are the most common cause of death and disability
around the world. The blood-brain barrier (BBB) is located at the interface between the CNS …

[HTML][HTML] Current clinical investigations of focused ultrasound blood-brain barrier disruption: a review

PG Durham, A Butnariu, R Alghorazi, G Pinton… - …, 2024 - Elsevier
The blood-brain barrier (BBB) presents a formidable challenge in delivering therapeutic
agents to the central nervous system. Ultrasound-mediated BBB disruption has emerged as …

Effects of sound interventions on the permeability of the blood–brain barrier and meningeal lymphatic clearance

S Sachdeva, S Persaud, M Patel, P Popard… - Brain Sciences, 2022 - mdpi.com
The meningeal lymphatic, or glymphatic, system is receiving increasing attention from the
scientific community. Recent work includes noninvasive techniques to demonstrate …