Sickle cell anaemia (SCD) is a life-threatening haematological disorder which is
predominant in sub-Saharan Africa and is triggered by a genetic mutation of the β-chain …

The majority of the global population of sickle cell disease (SCD) patients resides in Africa.
Individuals with this condition are at great risk of serious infections and early mortality …

Sickle cell disease (SCD) is caused by a point mutation in the beta-globin gene. SCD is
characterized by chronic hemolytic anemia, vaso-occlusive events leading to tissue …

Objective In patients with sickle cell disease (SCD), the spleen commonly enlarges during
early childhood, but undergoes reduction in size and fibrosis from repeated episodes of …

Background Sickle cell anemia (SCA) is a severe monogenic disorder, caused by single
nucleotide mutations in the hemoglobin (Hb) gene, that is prevalent in malaria endemic …

Abstract Background In Plasmodium falciparum infection, clinical conditions such as
anaemia, thrombocytopenia and leukocytosis are common. Mutation in haemoglobin sub …

Background Sickle cell disease (SCD) is a monogenic disorder due to point mutation in the
β-globin gene resulting in substitution of Valine for Glutamic acid. The SCD is prevalent in P …

Background Ultrasonography is an established and reliable method for assessing the
spleen. Because of variation due to genetic and other environmental factors including …

Background: Ultrasonography is an established and reliable method for assessing the
spleen. Because of variation due to genetic and other environmental factors including …

Sickle cell disease (SCD) is a collective name for a group of conditions that cause clinical
symptoms from the formation of sickled red cells. The spleen is one of the earliest organs …