The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

Beyond their important role in hemostasis, platelets play a crucial role in inflammatory
diseases. This becomes apparent during sepsis, where platelet count and activation …

Tissue microcirculation is essential for the maintenance of organ homeostasis. Following
acute infections, activation of coagulation and inflammation, which are critical …

Host defense against infection is based on two crucial mechanisms: the inflammatory
response and the activation of coagulation. Platelets are involved in both hemostasis and …

Platelets are small circulating anucleate cells that are of crucial importance in haemostasis.
Over the last decade, it has become increasingly clear that platelets play an important role in …

Beyond haemostasis, platelets have emerged as versatile effectors of the immune response.
The contribution of platelets in inflammation, tissue integrity and defence against infections …

Platelets play a variety of roles in vascular biology and are best recognized as primary
hemostasis and thrombosis mediators. Platelets have a large number of receptors and …

Sepsis is a life-threatening condition caused by a dysregulated host response to infection.
Although our understanding in the pathophysiological features of sepsis has increased …

Statins not only reduce levels of LDL-cholesterol, they counteract the inflammatory changes
associated with acute coronary syndrome and improve survival. Similarly, in patients …

Sepsis is the leading cause of critical illness and mortality in human beings and animals.
Neutrophils are the primary effector cells of innate immunity during sepsis. Besides …