Restriction-modification (RM) systems are ubiquitous and are often considered primitive
immune systems in bacteria. Their diversity and prevalence across the prokaryotic kingdom …

This article continues the series of Surveys and Summaries on restriction endonucleases
(REases) begun this year in Nucleic Acids Research. Here we discuss 'Type II'REases, the …

Proteins are probably the most important biomacromolecules and the building blocks of life.
They regulate a large number of diverse biological functions. Protein function depends …

The study of interactions of protein with DNA is important for gaining a fundamental
understanding of how numerous biological processes occur, including recombination …

AbaSI, a member of the PvuRts1I-family of modification-dependent restriction
endonucleases, cleaves deoxyribonucleic acid (DNA) containing 5-hydroxymethylctosine …

Interactions between distantly separated DNA regions mediated by specialized proteins
lead to the formation of synaptic protein− DNA complexes. This is a ubiquitous phenomenon …

DNA looping occurs in many important protein–DNA interactions, including those regulating
replication, transcription, and recombination. Recent theoretical studies predict that tension …

EcoRII restriction endonuclease is specific for the 5′-CCWGG sequence (W stands for A or
T); however, it shows no activity on a single recognition site. To activate cleavage it requires …

Most restriction endonucleases bridge two target sites before cleaving DNA: examples
include all of the translocating Type I and Type III systems, and many Type II nucleases …

To cut DNA at their target sites, restriction enzymes assemble into different oligomeric
structures. The Ecl18kI endonuclease in the crystal is arranged as a tetramer made of two …