T cells play a critical role in cancer control, but a range of potent immunosuppressive
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …

Extracellular nucleotides, mainly ATP, but also ADP, UTP, UDP and UDP-sugars,
adenosine, and adenine base participate in the “purinergic signalling” pathway, an …

The involvement of extracellular nucleotides and adenosine in an array of cell-specific
responses has long been known and appreciated, but the integrative view of purinergic …

This review article provides a historical perspective on the role of purinergic signalling in the
regulation of various subsets of immune cells from early discoveries to current …

As an approved vaccine adjuvant for use in humans, alum has vast health implications, but,
as it is a crystal, questions remain regarding its mechanism. Furthermore, little is known …

Adenosine is a key extracellular signalling molecule that regulates several aspects of tissue
function by activating four G-protein-coupled receptors, A1, A2A, A2B and A1 adenosine …

Adenosine (Ado) is a well-studied neurotransmitter, but it also exerts profound immune
regulatory functions. Ado can (i) actively be released by various cells into the tissue …

Binding of particulate antigens by antigen-presenting cells is a critical step in immune
activation. Previously, we demonstrated that uric acid crystals are potent adjuvants, initiating …

Adenosine regulates the interaction between lymphocytes and the vasculature, and is
important for controlling lymphocyte trafficking in response to tissue injury or infection …

The adenosine pathway is a powerful evolutionarily selected mechanism aimed at a fine
modulation of inflammatory responses and protection of tissues from injuries. Adenosine …