The NIH Comparative Genomics Resource: addressing the promises and challenges of comparative genomics on human health

K Bornstein, G Gryan, ES Chang, A Marchler-Bauer… - BMC genomics, 2023 - Springer
Comparative genomics is the comparison of genetic information within and across
organisms to understand the evolution, structure, and function of genes, proteins, and non …

A review of artificial intelligence based biological-tree construction: Priorities, methods, applications and trends

Z Zang, Y Xu, C Duan, J Wu, SZ Li, Z Lei - arXiv preprint arXiv:2410.04815, 2024 - arxiv.org
Biological tree analysis serves as a pivotal tool in uncovering the evolutionary and
differentiation relationships among organisms, genes, and cells. Its applications span …

[HTML][HTML] DNA repair and anti-cancer mechanisms in the longest-living mammal: the bowhead whale

D Firsanov, M Zacher, X Tian, Y Zhao, JC George… - BioRxiv, 2023 - biorxiv.org
At over 200 years, the maximum lifespan of the bowhead whale exceeds that of all other
mammals. The bowhead is also the second-largest animal on Earth, reaching over 80,000 …

A CDKN2C retroduplication in Bowhead whales is associated with the evolution of extremely long lifespans and alerted cell cycle dynamics

JM Vazquez, M Kraft, VJ Lynch - BioRxiv, 2022 - biorxiv.org
Among the constraints on the evolution of remarkably long lifespans is an increased risk of
developing cancer because organisms with long lifespans have more time to accumulate …

[HTML][HTML] Oncogenic processes: a neglected parameter in the evolutionary ecology of animals

F Thomas, K Asselin… - Comptes …, 2024 - comptes-rendus.academie-sciences …
Cancer is a biological process that emerged at the end of the Precambrian era with the rise
of multicellular organisms. Traditionally, cancer has been viewed primarily as a disease …

[HTML][HTML] Pervasive loss of regulated necrotic cell death genes in elephants, hyraxes, and sea cows (Paenungualta)

M Birkemeier, A Swindle, J Bowman, VJ Lynch - bioRxiv, 2024 - ncbi.nlm.nih.gov
Gene loss can promote phenotypic differences between species, for example, if a gene
constrains phenotypic variation in a trait, its loss allows for the evolution of a greater range of …

Extensive longevity and DNA virus-driven adaptation in nearctic Myotis bats

JM Vazquez, ME Lauterbur, S Mottaghinia, M Bucci… - bioRxiv, 2024 - biorxiv.org
The rich species diversity of bats encompasses extraordinary adaptations, including extreme
longevity and tolerance to infectious disease. While traditional approaches using genetic …

Évolution de la résistance au cancer dans le monde animal

F Thomas, B Ujvari, AM Dujon - médecine/sciences, 2024 - medecinesciences.org
Le cancer est un dommage collatéral inévitable inhérent à l'évolution des organismes
multicellulaires, apparus à la fin du Précambrien. L'exploration de la manière dont les …