Mining and unearthing hidden biosynthetic potential
K Scherlach, C Hertweck - Nature Communications, 2021 - nature.com
Genetically encoded small molecules (secondary metabolites) play eminent roles in
ecological interactions, as pathogenicity factors and as drug leads. Yet, these chemical …
ecological interactions, as pathogenicity factors and as drug leads. Yet, these chemical …
Mining genomes to illuminate the specialized chemistry of life
All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …
A computational framework to explore large-scale biosynthetic diversity
JC Navarro-Muñoz, N Selem-Mojica… - Nature chemical …, 2020 - nature.com
Genome mining has become a key technology to exploit natural product diversity. Although
initially performed on a single-genome basis, the process is now being scaled up to mine …
initially performed on a single-genome basis, the process is now being scaled up to mine …
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
The potential of the diverse chemistries present in natural products (NP) for biotechnology
and medicine remains untapped because NP databases are not searchable with raw data …
and medicine remains untapped because NP databases are not searchable with raw data …
BiG-FAM: the biosynthetic gene cluster families database
Computational analysis of biosynthetic gene clusters (BGCs) has revolutionized natural
product discovery by enabling the rapid investigation of secondary metabolic potential within …
product discovery by enabling the rapid investigation of secondary metabolic potential within …
The evolution of genome mining in microbes–a review
Covering: 2006 to 2016 The computational mining of genomes has become an important
part in the discovery of novel natural products as drug leads. Thousands of bacterial …
part in the discovery of novel natural products as drug leads. Thousands of bacterial …
Marine rare actinomycetes: a promising source of structurally diverse and unique novel natural products
R Subramani, D Sipkema - Marine drugs, 2019 - mdpi.com
Rare actinomycetes are prolific in the marine environment; however, knowledge about their
diversity, distribution and biochemistry is limited. Marine rare actinomycetes represent a …
diversity, distribution and biochemistry is limited. Marine rare actinomycetes represent a …
Marine natural products
Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382–431 This review covers the
literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for …
literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for …
Advances in decomposing complex metabolite mixtures using substructure-and network-based computational metabolomics approaches
Covering: up to the end of 2020 Recently introduced computational metabolome mining
tools have started to positively impact the chemical and biological interpretation of …
tools have started to positively impact the chemical and biological interpretation of …
Dereplication of microbial metabolites through database search of mass spectra
Natural products have traditionally been rich sources for drug discovery. In order to clear the
road toward the discovery of unknown natural products, biologists need dereplication …
road toward the discovery of unknown natural products, biologists need dereplication …