Immune checkpoint proteins (ICP) are currently one of the most novel and promising areas
of immune-oncology research. This novel way of targeting tumor cells has shown favorable …

Inflammatory bowel diseases (IBDs) are chronic problems of gastrointestinal tract (GIT) with
poorly understood aetiology. Patients with any of the two common entities, Crohn's disease …

The complement system is a critical immune component, yet its role in tumor immune
evasion and CD8+ T cell activation is not clearly defined. Here, we demonstrate that …

Viral infections cause substantial human morbidity and mortality, and are a significant health
burden worldwide. Following a viral infection, the host may initiate complex antiviral immune …

Many important pathogen-host interactions rely on highly specific carbohydrate binding
events. In the case of the protozoan Trypanosoma cruzi, the causative agent of Chagas …

The response of naive CD8+ T cells to their cognate antigen involves rapid and broad
changes to gene expression that are coupled with extensive chromatin remodeling, but the …

Background Multiple types of immune cells producing IL-17 are found in the tumor
microenvironment. However, their roles in tumor progression and exhaustion of CD8+ tumor …

Introduction Chronic infection with the protozoal parasite Trypanosoma cruzi leads to a
progressive cardiac disease, known as chronic Chagasic cardiomyopathy (CCC). A new …

Trypanosoma cruzi is a remarkably versatile parasite. It can parasitize almost any nucleated
cell type and naturally infects hundreds of mammal species across much of the Americas. In …

Chagas disease, a neglected tropical disease (NTD) caused by the flagellated protozoan
Trypanosoma cruzi (T. cruzi), is a major public health problem. It was initially restricted to …