We review the experimental evidence showing systemic and microvascular effects of blood
transfusions instituted to support the organism in extreme hemodilution and hemorrhagic …

The hallmark of sickle cell disease is the polymerization of sickle haemoglobin due to a point
mutation in the β‐globin gene (HBB). Under low oxygen saturation, sickle haemoglobin …

Cisplatin-induced acute kidney injury (AKI) is an important factor that limits the clinical use of
this drug for the treatment of malignancies. Oxidative stress and inflammation are …

A simple and green ionic liquid-based vortex-forced matrix solid phase dispersion (IL-
VFMSPD) method was presented to simultaneously extract 5-hydroxymethyl furfurol (5-HMF) …

In an attempt to find new types of anti-hypoxic agents from herbs, we identified 5-
hydroxymethyl-2-furfural (5-HMF) as a natural agent that fulfills the criterion. 5-HMF, the final …

Covalent core–shell structured protein clusters of hemoglobin (Hb) and human serum
albumin (HSA)(Hb X-HSA m)(m= 2, 3) with novel physiological properties were generated …

Doxorubicin (DOX) is one of the most widely used anticancer agents. DOX is known for
inducing cardiotoxicity, resulting in the long-term development of heart failure. Intravascular …

Background: Increased microcirculatory flow and perfusion has been reported to improve
clinical outcomes following shock. The optimal resuscitation fluid to restore the flow …

Background Current blood banking procedures may not fully preserve red blood cell (RBC)
function during storage, contributing to the decrease of RBC oxygen release ability. This …

Acclimatization to hypoxia requires time to complete the adaptation mechanisms that
influence oxygen (O2) transport and O2 utilization. Although decreasing hemoglobin (Hb) …