Although flavonoid compounds have various pharmacological applications, they generally
exhibit low oral bioavailability due to their poor aqueous solubility. To address this problem …

The use of herbal medicines has gained popularity throughout the world in recent times.
Often seen as natural alternatives with fewer side-effects than synthetic medicines, these …

The apigenin-phospholipid phytosome (APLC) was developed to improve the aqueous
solubility, dissolution, in vivo bioavailability, and antioxidant activity of apigenin. The APLC …

Background: Cyclodextrins (CDs) are versatile excipients with an essential role in drug
delivery, as they can form non-covalently bonded inclusion complexes (host-guest …

Introduction: Poor solubility and dissolution of drugs are the major challenges in drug
formulation and delivery. In order to improve the solubility and dissolution profile of drugs …

Objectives The main objective of the present review is to explore and examine the
effectiveness of currently developed novel techniques to resolve the issues which are …

Background: Naringenin (NAR) is a flavonoid with excellent antioxidant and neuroprotective
potential that is limited by its low solubility. Thus, solid dispersions with β-cyclodextrin (β …

The purpose of the present study was to improve the aqueous solubility of naringenin by
conjugating with water-soluble polysaccharide carrier, pectin. The pectin–naringenin …

It is well known that the limited aqueous solubility of some drugs often reduces their
bioavailability to targets. Inclusion complex formation of drugs with β-cyclodextrin is one of …

Cyclodextrins (CDs) are interesting and applicable nanocarriers in the form of cyclic
oligosaccharides produced from the hydrolytic process of starch degradation due to their …