Psoriasis is a complex, chronic relapsing and inflammatory skin disorder with a prevalence
of approximately 2% in the general population worldwide. Psoriasis can be triggered by …

In recent years, the understanding of regulatory T cell (Treg cell) biology has expanded
considerably. Key observations have challenged the traditional definition of Treg cells and …

Simple Summary Immunotherapy improved the therapeutic landscape for patients with
advanced cancer diseases. However, many patients do not benefit from immunotherapy …

Autoimmune diseases, such as Systemic Lupus Erythematosus (SLE) or Rheumatoid
Arthritis (RA) are characterized by the breakdown of immunological tolerance. Defects of …

CD4+ T helper cells are a central element of the adaptive immune system. They protect the
organism against a wide range of pathogens and are able to initiate and control many …

Regulatory (Treg) cells are key regulators of inflammation and important for immune
tolerance and homeostasis. A major progress has been made in the identification and …

Infection or sterile inflammation triggers site-specific attraction of leukocytes. Leukocyte
recruitment is a process comprising several steps orchestrated by adhesion molecules …

Regulatory T cells are the central element for the maintenance of peripheral tolerance.
Several subtypes of regulatory T (Treg) cells have been described, and most of them belong …

Background IL-17 and Foxp3 double-expressing (DE) CD4+ T lymphocytes are novel
crossover immune cell population, but the presence and role of these cells in human …

β2 integrins are heterodimeric surface receptors composed of a variable α (CD11a-CD11d)
and a constant β (CD18) subunit and are specifically expressed by leukocytes. The α …