Owing to their ability to efficiently generate ATP required to sustain normal cell function,
mitochondria are often considered the 'powerhouses of the cell'. However, our …

Abstract Mitochondria contain about 1,000–1,500 proteins that fulfil multiple functions.
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …

Cardiomyopathy and heart failure are common manifestations in mitochondrial disease
caused by deficiencies in the oxidative phosphorylation (OXPHOS) system of mitochondria …

In mammalian cells, mitochondrial dysfunction triggers the integrated stress response, in
which the phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) results in the …

Mitochondria are essential organelles that execute and coordinate various metabolic
processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes …

In animals, mitochondria are mainly organised into an interconnected tubular network
extending across the cell along a cytoskeletal scaffold. Mitochondrial fission and fusion, as …

Mitochondrial fidelity is tightly linked to overall cellular homeostasis and is compromised in
ageing and various pathologies,–. Mitochondrial malfunction needs to be relayed to the …

Mitochondrial morphology varies tremendously across cell types and tissues, changing
rapidly in response to external insults and metabolic cues, such as nutrient status. The many …

Mitochondria are renowned for their central bioenergetic role in eukaryotic cells, where they
act as powerhouses to generate adenosine triphosphate from oxidation of nutrients. At the …

Mitochondrial stress activates a mitonuclear response to safeguard and repair mitochondrial
function and to adapt cellular metabolism to stress. Using a multiomics approach in …