γ-Butyrolactone, a five-membered lactone moiety, is one of the privileged structures of
diverse natural products and biologically active small molecules. Because of their broad …

The development of bacterial resistance to antibiotics and the consequent lack of effective
therapy is one of the biggest problems in modern medicine. A consequence of these …

Neisseria gonorrhoeae is an urgent threat to public health in the United States and around
the world. Many of the current classes of antibiotics to treat N. gonorrhoeae infection are …

Neisseria gonorrhoeae is a high-priority pathogen of concern due to the growing prevalence
of resistance development against approved antibiotics. Herein, we report the anti …

Developing fungicides from active botanical skeletons is one of the effective methods to
tackle the resistance of plant pathogens. Based on our previous discoveries, a series of …

Antibiotic-resistant bacteria represent a serious threat to modern medicine and human life.
Only a minority of antibacterial agents are active against Gram-negative bacteria. Hence, the …

Clostridioides difficile infection is a global health threat and remains the primary cause of
hospital-acquired infections worldwide. The burgeoning incidence and severity of infections …

Infectious diseases have always been a concern for human health, responsible for
numerous pandemics throughout history. Even with the advancement of medicine, new …

Abstract γ‐butyrolactones and their derivatives serve as the fundamental building blocks for
a wide range of biologically significant and synthetically challenging natural products, which …

Clostridioides difficile is an enteric pathogen responsible for causing debilitating diarrhea,
mostly in hospitalized patients. The bacterium exploits on microbial dysbiosis induced by the …