The emergence of multi-drug resistance makes bacterial infection a major threat to public
health and economy. The formation of bacterial biofilms is one of the main reasons of …

As more antibiotics are rendered ineffective by drug-resistant bacteria, focus must be shifted
towards alternative therapies for treating infections. Although several alternatives already …

Global health is increasingly being threatened by the rapid emergence of drug-resistant
microbes. The ability of these microbes to form biofilms has further exacerbated the scenario …

Vancomycin, a natural glycopeptide antibiotic, was used as the antibiotic of last resort for the
treatment of multidrug-resistant Gram-positive bacterial infections. However, almost 30 years …

More than 80% of the bacterial infections are associated with biofilm formation. To combat
infections, amphiphilic small molecules have been developed as promising antibiofilm …

An optimum hydrophilic/hydrophobic balance has been recognized as a crucial parameter
in designing cationic polymers that mimic antimicrobial peptides (AMPs). To date, this …

Membrane-active small molecules (MASMs) are small organic molecules designed to
reproduce the fundamental physicochemical properties of natural antimicrobial peptides …

Interkingdom polymicrobial biofilms formed by Gram-positive Staphylococcus aureus and
Candida albicans pose serious threats of chronic systemic infections due to the absence of …

The priority pathogen list published by the World Health Organization (WHO) has
categorized carbapenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa …

Infections caused by drug-resistant bacteria have emerged to be one of the greatest threats
to global public health, and new antimicrobial agents with novel mechanisms of action …