The recapitulation of the material properties and structure of the native aortic valve leaflet,
specifically its anisotropy and laminate structure, is a major design goal for scaffolds for …

The utility of bioprosthetic heart valves (BHVs) is limited to certain patient populations
because of their poor durability compared to mechanical prosthetic valves. Histological …

Mechanical testing of soft tissues would ideally rely on using fresh specimens. In the event
that fresh tissues are not readily available, alternative measures, such as storing fresh …

The details of valvular leaflet healing following valvuloplasty and leaflet perforation from
endocarditis are poorly understood. In this study, the synthesis and turnover of valvular …

Heart valve (HV) diseases are among the leading causes of cardiac failure and deaths. Of
the various HV diseases, damaged HV leaflets are among the primary culprits. In many …

The growing global burden of valvular heart disease (VHD) remains a significant challenge
to overcome. Despite the advancements in heart valve replacements and the ground …

Heart valve disease can affect people of all ages, and can be treated by either valve repair
or valve replacement surgery. Currently available replacement heart valves, including …

The aortic valve is composed of collagen, elastin, proteoglycan, valvular interstitial cells
(VIC), and valvular endothelial cells (VEC). In the open condition, the aorta valve allows …

Aortic valve disease initiates on the fibrosa (aorta-facing) side of the valve leaflets, whereas
the ventricularis side is disease-protected. Spatially predictable disease correlates with side …

Valvular heart disease affects about 2.5% of the United States population and its incidence
is projected to increase as a result of the increasing global prevalence of cardiometabolic …