Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …

Mast cells and basophils are key contributors to allergies and other inflammatory diseases
since they are the most prominent source of histamine as well as numerous additional …

The pathophysiological roles of mast cells are still not fully understood, over 140 years since
their description by Paul Ehrlich in 1878. Initial studies have attempted to identify distinct …

The perspective of neuroinflammation as an epiphenomenon following neuron damage is
being replaced by the awareness of glia and their importance in neural functions and …

Mast cells (MCs) are recognized to participate in the regulation of innate and adaptive
immune responses. Owing to their strategic location at the host–environment interface, they …

Background Carcinogenesis is widely thought to originate from somatic mutations and an
inhibition of growth suppressors, followed by cell proliferation, tissue invasion, and risk of …

Asthma is an inflammatory disease of the airways associated with a T helper (Th) 2
response. Such a response in the lungs requires complex interactions between innate cells …

The liver is frequently exposed to potentially toxic materials, and it is the primary site of
clearance of foreign agents, along with many innate and adaptive immune cells …

Although mast cells (MCs) are known as key drivers of type I allergic reactions, there is
increasing evidence for their critical role in host defense. MCs not only play an important role …

Mast cells are phenotypically and functionally heterogeneous, and their state is possibly
controlled by local microenvironment. Therefore, specific analyses are needed to …