Artemisinins–the frontline antimalarial drug class–are compromised by emerging resistance,
putting at risk the lives of hundreds of thousands of people each year. Resistance is …

Apicomplexa are obligate intracellular parasites responsible for major human infectious
diseases such as toxoplasmosis and malaria, which pose social and economic burdens …

The malaria parasite Plasmodium falciparum undergoes closed mitosis, which occurs within
an intact nuclear envelope, and differs significantly from its human host. Mitosis is …

The emergence and spread of Plasmodium falciparum resistance to first-line antimalarials
creates an imperative to identify and develop potent preclinical candidates with distinct …

Background Plasmodium falciparum is the pathogen responsible for the most devastating
form of human malaria. As it replicates asexually in the erythrocytes of its human host, the …

During intraerythrocytic growth, the human malaria parasite Plasmodium falciparum
degrades up to 80% of the host cell's hemoglobin inside an acidified organelle called the …

Studies of the susceptibility of Plasmodium falciparum to the artemisinin family of
antimalarial drugs provide a complex picture of partial resistance (tolerance) associated with …

Artemisinin and its derivatives (ART) are the cornerstone of malaria treatment as part of
artemisinin combination therapy (ACT). However, reduced susceptibility to artemisinin as …

Proteins of the lipocalin family are known to bind small hydrophobic ligands and are
involved in various physiological processes ranging from lipid transport to oxidative stress …

The malaria parasite resides within erythrocytes during one stage of its life cycle. During this
intraerythrocytic period, the parasite ingests the erythrocyte cytoplasm and digests …