Voltage-gated ion channels are crucial for both neuronal and cardiac excitability. Decades
of research have begun to unravel the intriguing machinery behind voltage sensitivity …

The IKs channel complex is formed by the co-assembly of Kv7. 1 (KCNQ1), a voltage-gated
potassium channel, with its β-subunit, KCNE1 and the association of numerous accessory …

The voltage-sensing domain of voltage-gated channels is comprised of four transmembrane
helices (S1–S4), with conserved positively charged residues in S4 moving across the …

The rising interest in Kv7 modulators originates from their ability to evoke fundamental
electrophysiological perturbations in a tissue-specific manner. A large number of therapeutic …

Obesity and its associated metabolic dysregulation leading to metabolic syndrome is an
epidemic that poses a significant public health problem. More than one-third of the world …

The Hv1 proton channel is unique among voltage-gated channels for containing the pore
and gate within its voltage-sensing domain. Pore opening has been proposed to include …

Human IKs channels activate slowly with the onset of cardiac action potentials to repolarize
the myocardium. IKs channels are composed of KCNQ1 (Q1) pore-forming subunits that …

In voltage-gated K+ channels, membrane depolarization induces an upward movement of
the voltage-sensing domains (VSD) that triggers pore opening. KCNQ1 is a voltage-gated …

Human mutations in the CACNA1A gene that encodes the pore-forming α 1A subunit of the
voltage-gated Ca V 2.1 (P/Q-type) Ca 2+ channel cause multiple neurological disorders …

Relating ion channel (iCh) structural dynamics to physiological function remains a
challenge. Current experimental and computational techniques have limited ability to …