The formation and spreading of amyloid aggregates from the presynaptic protein α-
synuclein in the brain play central roles in the pathogenesis of Parkinson's disease. Here …

Amyloid proteins are characterized by their tendency to aggregate into amyloid fibrils, which
are often associated with devastating diseases. Aggregation pathways typically involve …

Human calcitonin (hCT) is a polypeptide hormone that participates in calcium-phosphorus
metabolism. Irreversible aggregation of 32-amino acid hCT into β-sheet-rich amyloid fibrils …

A deep understanding of the early molecular mechanism of amyloid beta peptides (Aβ) is
crucial to develop therapeutic and preventive approaches for Alzheimer's disease (AD) …

The physical stability of peptide-based drugs is of great interest to the pharmaceutical
industry. Glucagon-like peptide 1 (GLP-1) is a 31-amino acid peptide hormone, the analogs …

Glucagon is a 29-amino acid peptide hormone secreted by pancreatic α-cells and interacts
with specific receptors located in various organs. Glucagon tends to form gel-like fibril …

Proton magic-angle-spinning NMR used for real-time analysis of amyloid aggregation
reveals that mechanical rotation of Aβ1–40 monomers increases the rate of formation of …

Some therapeutic peptides self-assemble in solution to form ordered, insoluble, β-sheet-rich
amyloid fibrils. This physical instability can result in reduced potency, cause immunogenic …

Glucagon is a 29 amino acid peptide hormone secreted by pancreatic α-cells that interacts
with specific receptors located in various organs. Glucagon tends to form gel-like fibrillar …

The formation of fibrillar aggregates of the amyloid beta peptide (Aβ) in the brain is one of
the hallmarks of Alzheimer's disease (AD). A clear understanding of the different …