During development, both cells and tissues must acquire the correct shape to allow their
proper function. This is especially relevant in the nervous system, where the shape of …

Malformations of cerebral cortical development include a wide range of developmental
disorders that are common causes of neurodevelopmental delay and epilepsy. In addition …

During vertebrate development, a wide variety of cell types and tissues emerge from a single
fertilized oocyte. One of these tissues, the central nervous system, contains many types of …

A major cause of the cerebral cortex expansion that occurred during evolution is the
increase in subventricular zone (SVZ) progenitors. We found that progenitors in the outer …

An astonishing number of extracellular matrix glycoproteins are expressed in dynamic
patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia …

Although many features of neurogenesis during development and in the adult are intrinsic to
the neurogenic cells themselves, the role of the microenvironment is irrefutable. The …

De novo germline mutations in the RNA helicase DDX3X account for 1%–3% of
unexplained intellectual disability (ID) cases in females and are associated with autism …

The evolutionary expansion of the mammalian neocortex (Ncx) is thought to be linked to
increased proliferative capacity of basal progenitors (BPs) and their neurogenic capacity …

The neural circuits of the mammalian neocortex are crucial for perception, complex thought,
cognition, and consciousness. This circuitry is assembled from many different neuronal …

Neural stem and progenitor cells giving rise to neurons in developing mammalian neocortex
fall into two principal classes with regard to location of mitosis—apical and basal, and into …