Purpose The impact of a personalized cancer treatment strategy (ie, matching patients with
drugs based on specific biomarkers) is still a matter of debate. Methods We reviewed phase …

Targeted therapies and the consequent adoption of “personalized” oncology have achieved
notable successes in some cancers; however, significant problems remain with this …

Importance The impact of a biomarker-based (personalized) cancer treatment strategy in the
setting of phase 1 clinical trials was analyzed. Objective To compare patient outcomes in …

To evaluate the potential of an integrated clinical test to detect diverse classes of somatic
and germline mutations relevant to pediatric oncology, we performed three-platform whole …

BACKGROUND A clinical assay was implemented to perform next‐generation sequencing
(NGS) of genes commonly mutated in multiple cancer types. This report describes the …

Advances in our knowledge of the molecular pathogenesis of cancer have led to increased
interest in molecularly targeted agents (MTAs), which target specific oncogenic drivers and …

Adenosquamous carcinoma of the pancreas (ASCP) is a rare entity. Like adenocarcinoma of
the pancreas, overall survival is poor. Characteristics of ASCP include central tumor …

Advancements in next-generation sequencing have greatly enhanced the development of
biomarker-driven cancer therapies. The affordability and availability of next-generation …

Primary immunodeficiencies (PIDs) are inborn errors of the immune system. PIDs have been
characterized immunologically for the last 60 years and genetically, principally by Sanger …

The human gut microbiota consists of about 3.8× 10 13 microorganisms that play an
essential role in health, metabolism, and immunomodulation. These gut microbes alter …