The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2

L Bauer, BM Laksono, FMS de Vrij, SA Kushner… - Trends in …, 2022 - cell.com
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection is associated with
a diverse spectrum of neurological complications during the acute and postacute stages …

Golden Syrian hamster models for cancer research

Z Wang, RT Cormier - Cells, 2022 - mdpi.com
The golden Syrian hamster (Mesocricetus auratus) has long been a valuable rodent model
of human diseases, especially infectious and metabolic diseases. Hamsters have also been …

Brain inflammation and intracellular α-synuclein aggregates in macaques after SARS-CoV-2 infection

IH Philippens, KP Böszörményi, JAM Wubben… - Viruses, 2022 - mdpi.com
SARS-CoV-2 causes acute respiratory disease, but many patients also experience
neurological complications. Neuropathological changes with pronounced …

Broad protection against clade 1 sarbecoviruses after a single immunization with cocktail spike-protein-nanoparticle vaccine

PJ Halfmann, K Loeffler, A Duffy, M Kuroda… - Nature …, 2024 - nature.com
The 2002 SARS outbreak, the 2019 emergence of COVID-19, and the continuing evolution
of immune-evading SARS-CoV-2 variants together highlight the need for a broadly …

An FcRn-targeted mucosal vaccine against SARS-CoV-2 infection and transmission

W Li, T Wang, AM Rajendrakumar, G Acharya… - Nature …, 2023 - nature.com
SARS-CoV-2 is primarily transmitted through droplets and airborne aerosols, and in order to
prevent infection and reduce viral spread vaccines should elicit protective immunity in the …

Removal of hypersignaling endosomes by simaphagy

SM Migliano, SW Schultz, EM Wenzel, S Takáts, D Liu… - Autophagy, 2024 - Taylor & Francis
Activated transmembrane receptors continue to signal following endocytosis and are only
silenced upon ESCRT-mediated internalization of the receptors into intralumenal vesicles …

[HTML][HTML] Transchromosomic bovine-derived anti-SARS-CoV-2 polyclonal human antibodies protects hACE2 transgenic hamsters against multiple variants

T Gilliland, M Dunn, Y Liu, MDH Alcorn, Y Terada… - Iscience, 2023 - cell.com
Pandemic SARS-CoV-2 has undergone rapid evolution resulting in the emergence of many
variants with mutations in the spike protein, some of which appear to evade antibody …

Characterization of Omicron BA. 4.6, XBB, and BQ. 1.1 subvariants in hamsters

PJ Halfmann, K Iwatsuki-Horimoto, M Kuroda… - Communications …, 2024 - nature.com
During the Omicron wave, previous variants such as BA. 2, BA. 4, and BA. 5 were replaced
by newer variants with additional mutations in the spike protein. These variants, BA. 4.6, BQ …

Animal models for studying COVID-19, prevention, and therapy: Pathology and disease phenotypes

S Choudhary, I Kanevsky… - Veterinary Pathology, 2022 - journals.sagepub.com
Translational models have played an important role in the rapid development of safe and
effective vaccines and therapeutic agents for the ongoing coronavirus disease 2019 (COVID …

Inflammatory response and defects on myelin integrity in the olfactory system of K18hACE2 mice infected with SARS-CoV-2

E Martin-Lopez, B Brennan, T Mao, N Spence… - eneuro, 2024 - eneuro.org
Viruses, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), use
respiratory epithelial cells as an entry point for infection. Within the nasal cavity, the olfactory …