Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Thirty-five years after the identification of HIV-1 as the causative agent of AIDS, we are still in
search of vaccines and treatments to eradicate this devastating infectious disease. Progress …

Transcriptional deregulation is a hallmark of many cancers and is exemplified by genomic
amplifications of the MYC family of oncogenes, which occur in at least 20% of all solid …

The super elongation complex (SEC) is required for robust and productive transcription
through release of RNA polymerase II (Pol II) with its P-TEFb module and promoting …

The general mechanism involved in Tat activation of RNA Polymerase II (RNAP II)
elongation of the integrated HIV-1 was elucidated over 20 years ago. This mechanism …

Promoter-proximal pausing by RNA Pol II is a rate-determining step in gene transcription
that is hypothesized to be a prominent point at which regulatory factors act. The pausing …

To prevail in the interaction with eukaryotic hosts, many bacterial pathogens use protein
secretion systems to release virulence factors at the host–pathogen interface and/or deliver …

DNA damage response (DDR) involves dramatic transcriptional alterations, the mechanisms
of which remain ill defined. Here, we show that following genotoxic stress, the RNA-binding …

Inhibition of host cell apoptosis is crucial for survival and replication of several intracellular
bacterial pathogens. To interfere with apoptotic pathways, some pathogens use specialized …

Transcriptional circuit architectures in several organisms have been evolutionarily selected
to dictate precise given responses. Unlike these cellular systems, HIV is regulated through a …