Fibroblast growth factor receptors (FGFRs) regulate diverse cellular behaviors that should
be exquisitely controlled in space and time. We engineered an optically controlled FGFR …

Purpose: The FGFR1 gene is amplified in 14% of patients with HR+/HER2− breast cancer.
Efficacy and safety of lucitanib, an inhibitor of VEGFR1-3, FGFR1-3, and PDGFRα/β, were …

We have in recent years described several endothelial-specific genes that mediate cell
migration. These include Robo4 (roundabout 4), CLEC14A (C-type lectin 14A) and ECSCR …

Purpose A two-stage genome-wide association study was carried out in head and neck
cancer (HNC) patients aiming to identify genetic variants associated with either specific …

Cancer cell-derived extracellular vesicles (EVs) have extensive application in the formation
of their environment, including metastasis. This study explored the ability of gastric cancer …

Background Hepatic stellate cell (HSC) plays a key role in pathogenesis of liver fibrosis.
During liver injury, hypoxia in local micro-environment is inevitable. Hif-1α is the key …

Vitiligo is a depigmentation disorder characterized by loss of functional melanocytes of the
skin epidermis. The pathogenesis of vitiligo remains elusive. The purpose of this study is to …

Angiogenesis is the result of the combined activity of the tumor microenvironment and
signaling molecules. The angiogenic switch is represented as an imbalance between pro …

Abstract The Ras/Raf/ERK1/2 signaling pathway controls many cellular responses such as
cell proliferation, migration, differentiation, and death. In the nervous system, emerging …

ARHI is an imprinted tumor suppressor gene that is downregulated in> 60% of ovarian
cancers, associated with decreased progression-free survival. ARHI encodes a 26 kDa …