The expanding role of prodrugs in contemporary drug design and development
J Rautio, NA Meanwell, L Di… - Nature reviews drug …, 2018 - nature.com
Prodrugs are molecules with little or no pharmacological activity that are converted to the
active parent drug in vivo by enzymatic or chemical reactions or by a combination of the two …
active parent drug in vivo by enzymatic or chemical reactions or by a combination of the two …
Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives
Cancer is considered as one of the most serious health problems today. The discovery of
nitrogen mustard as an alkylating agent in 1942, opened a new era in the cancer …
nitrogen mustard as an alkylating agent in 1942, opened a new era in the cancer …
Anticancer therapy targeting the apoptotic pathway
W Hu, JJ Kavanagh - The lancet oncology, 2003 - thelancet.com
Apoptosis, or programmed cell death, has an essential role in controlling cell number in
many developmental and physiological settings and in chemotherapy-induced tumour-cell …
many developmental and physiological settings and in chemotherapy-induced tumour-cell …
Enzyme-catalyzed activation of anticancer prodrugs
M Rooseboom, JNM Commandeur… - Pharmacological …, 2004 - ASPET
The rationale for the development of prodrugs relies upon delivery of higher concentrations
of a drug to target cells compared to administration of the drug itself. In the last decades …
of a drug to target cells compared to administration of the drug itself. In the last decades …
Glutathione S-transferases: an overview in cancer research
G Di Pietro, LAV Magno… - Expert opinion on drug …, 2010 - Taylor & Francis
Importance of the field: The Glutathione S-transferases (GSTs) have advanced beyond the
classic view of their role in metabolism and are encouraging scientists to assess new …
classic view of their role in metabolism and are encouraging scientists to assess new …
The mercapturic acid pathway
PE Hanna, MW Anders - Critical reviews in toxicology, 2019 - Taylor & Francis
The mercapturic acid pathway is a major route for the biotransformation of xenobiotic and
endobiotic electrophilic compounds and their metabolites. Mercapturic acids (N-acetyl-l …
endobiotic electrophilic compounds and their metabolites. Mercapturic acids (N-acetyl-l …
Pyrrolbenzodiazepines
DE Thurston, PW Howard - US Patent 7,049,311, 2006 - Google Patents
2017-04-11 Assigned to MEDIMMUNE LIMITED reassignment MEDIMMUNE LIMITED
CORRECTIVE ASSIGNMENT TO CORRECT THE POSTAL CODE OF THE ASSIGNEE …
CORRECTIVE ASSIGNMENT TO CORRECT THE POSTAL CODE OF THE ASSIGNEE …
Glutathione S-conjugates as prodrugs to target drug-resistant tumors
EE Ramsay, PJ Dilda - Frontiers in pharmacology, 2014 - frontiersin.org
Living organisms are continuously exposed to xenobiotics. The major phase of enzymatic
detoxification in many species is the conjugation of activated xenobiotics to reduced …
detoxification in many species is the conjugation of activated xenobiotics to reduced …
Glutathione S-transferase π: a potential role in antitumor therapy
SC Dong, HH Sha, XY Xu, TM Hu, R Lou… - Drug design …, 2018 - Taylor & Francis
Glutathione S-transferase π (GSTπ) is a Phase II metabolic enzyme that is an important
facilitator of cellular detoxification. Traditional dogma asserts that GSTπ functions to catalyze …
facilitator of cellular detoxification. Traditional dogma asserts that GSTπ functions to catalyze …
Pyrrolobenzodiazepines
DE Thurston, PW Howard - US Patent 7,067,511, 2006 - Google Patents
2017-04-11 Assigned to MEDIMMUNE LIMITED reassignment MEDIMMUNE LIMITED
CORRECTIVE ASSIGNMENT TO CORRECT THE POSTAL CODE OF THE ASSIGNEE …
CORRECTIVE ASSIGNMENT TO CORRECT THE POSTAL CODE OF THE ASSIGNEE …