Prevalence and disease burden of chronic kidney disease

JC Lv, LX Zhang - Renal fibrosis: mechanisms and therapies, 2019 - Springer
Chronic kidney disease (CKD) has been recognized as a leading public health problem
worldwide. The global estimated prevalence of CKD is 13.4%(11.7–15.1%), and patients …

Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases

A Ståhl, K Johansson, M Mossberg, R Kahn… - Pediatric …, 2019 - Springer
Extracellular vesicles are cell-derived membrane particles ranging from 30 to 5,000 nm in
size, including exosomes, microvesicles, and apoptotic bodies. They are released under …

SARS-CoV-2 initiates programmed cell death in platelets

M Koupenova, HA Corkrey, O Vitseva… - Circulation …, 2021 - Am Heart Assoc
Rationale: Coronavirus disease 2019 (COVID-19) is characterized by increased incidence
of microthrombosis with hyperactive platelets sporadically containing viral RNA. It is unclear …

Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro

CC Chen, L Liu, F Ma, CW Wong, XE Guo… - Cellular and molecular …, 2016 - Springer
The delivery of therapeutics to the central nervous system remains a major challenge in part
due to the presence of the blood–brain barrier (BBB). Recently, cell-derived vesicles …

Extracellular vesicles in renal disease

D Karpman, A Ståhl, I Arvidsson - Nature Reviews Nephrology, 2017 - nature.com
Extracellular vesicles, such as exosomes and microvesicles, are host cell-derived packages
of information that allow cell–cell communication and enable cells to rid themselves of …

The transport mechanism of extracellular vesicles at the blood-brain barrier

J Matsumoto, T Stewart, WA Banks… - Current pharmaceutical …, 2017 - ingentaconnect.com
Recently, extracellular vesicles (EVs), like exosomes and microvesicles, have attracted
attention as potent carriers of intercellular communication throughout the body, including the …

Microvesicles in vascular homeostasis and diseases

VC Ridger, CM Boulanger… - Thrombosis and …, 2017 - thieme-connect.com
Microvesicles are members of the family of extracellular vesicles shed from the plasma
membrane of activated or apoptotic cells. Microvesicles were initially characterised by their …

Microparticles: biomarkers and beyond

D Burger, S Schock, CS Thompson… - Clinical …, 2013 - portlandpress.com
Membrane microparticles are submicron fragments of membrane shed into extracellular
space from cells under conditions of stress/injury. They may be distinguished from other …

Extracellular vesicles: exosomes, microparticles, their parts, and their targets to enable their biomanufacturing and clinical applications

CY Kao, ET Papoutsakis - Current opinion in biotechnology, 2019 - Elsevier
Highlights•There are two types of extracellular vesicles (EVs): the submicron-size
microparticles and the nanometer-size exosomes.•EVs are generated from mammalian cells …

Platelet-derived microvesicles in cardiovascular diseases

MTK Zaldivia, JD McFadyen, B Lim, X Wang… - Frontiers in …, 2017 - frontiersin.org
Microvesicles (MVs) circulating in the blood are small vesicles (100–1,000 nm in diameter)
derived from membrane blebs of cells such as activated platelets, endothelial cells, and …