The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo
differentiation into osteoblasts. This differentiation process plays a crucial role in bone …

RUNX1 is a member of the core-binding factor family of transcription factors and is
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …

Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …

Bone metabolism is regulated by the cooperative activity between bone-forming osteoblasts
and bone-resorbing osteoclasts. However, the mechanisms mediating the switch between …

A transcription factor, Cbfa1, which belongs to the runt-domain gene family, is expressed
restrictively in fetal development. To elucidate the function of Cbfa1, we generated mice with …

The osteoblast is the bone-forming cell. The molecular basis of osteoblast-specific gene
expression and differentiation is unknown. We previously identified an osteoblast-specific …

The AML1–CBFβ transcription factor is the most frequent target of chromosomal
rearrangements in human leukemia. To investigate its normal function, we generated mice …

Differentiation of mesenchymal stem cells into a particular lineage is tightly regulated, and
malfunction of this regulation could lead to pathological consequences. Patients with …

Cleidocranial dysplasia (CCD) is an autosomal-dominant condition characterized by
hypoplasia/aplasia of clavicles, patent fontanelles, supernumerary teeth, short stature, and …

The major event that triggers osteogenesis is the transition of mesenchymal stem cells into
bone forming, differentiating osteoblast cells. Osteoblast differentiation is the primary …