Cellular and molecular mechanisms of allergic asthma
Asthma is a chronic disease of the airways, which affects more than 350 million people
worldwide. It is the most common chronic disease in children, affecting at least 30 million …
worldwide. It is the most common chronic disease in children, affecting at least 30 million …
Airway smooth muscle pathophysiology in asthma
B Camoretti-Mercado, RF Lockey - Journal of Allergy and Clinical …, 2021 - Elsevier
The airway smooth muscle (ASM) cell plays a central role in the pathogenesis of asthma and
constitutes an important target for treatment. These cells control muscle tone and thus …
constitutes an important target for treatment. These cells control muscle tone and thus …
Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study
Background Few genetic studies that focus on moderate-to-severe asthma exist. We aimed
to identity novel genetic variants associated with moderate-to-severe asthma, see whether …
to identity novel genetic variants associated with moderate-to-severe asthma, see whether …
Recent findings in the genetics and epigenetics of asthma and allergy
M Kabesch, J Tost - Seminars in immunopathology, 2020 - Springer
In asthma and allergy genetics, a trend towards a few main topics developed over the last 2
years. First, a number of studies have been published recently which focus on overlapping …
years. First, a number of studies have been published recently which focus on overlapping …
The role of epigenetics in allergy and asthma development
BA Alhamwe, F Alhamdan, A Ruhl… - Current opinion in …, 2020 - journals.lww.com
The role of epigenetics in allergy and asthma development : Current Opinion in Allergy and
Clinical Immunology The role of epigenetics in allergy and asthma development : Current …
Clinical Immunology The role of epigenetics in allergy and asthma development : Current …
Cell-specific DNA methylation signatures in asthma
AA Hudon Thibeault, C Laprise - Genes, 2019 - mdpi.com
Asthma is a complex trait, often associated with atopy. The genetic contribution has been
evidenced by familial occurrence. Genome-wide association studies allowed for associating …
evidenced by familial occurrence. Genome-wide association studies allowed for associating …
Reduced expression of miR-146a in human bronchial epithelial cells alters neutrophil migration
A Kivihall, A Aab, J Soja, K Sładek, M Sanak… - Clinical and …, 2019 - Springer
Background The role of miRNAs in the pathogenesis and determining the phenotypes of
asthma is not fully elucidated. miR-146a has been previously shown to suppress …
asthma is not fully elucidated. miR-146a has been previously shown to suppress …
Epigenetics and the environment in airway disease: asthma and allergic rhinitis
Asthma and rhinitis are complex, heterogeneous diseases characterized by chronic
inflammation of the upper and lower airways. While genome-wide association studies …
inflammation of the upper and lower airways. While genome-wide association studies …
Epigenetic changes in airway smooth muscle as a driver of airway inflammation and remodeling in asthma
KA Kaczmarek, RL Clifford, AJ Knox - Chest, 2019 - Elsevier
Epigenetic changes are heritable changes in gene expression, without changing the DNA
sequence. Epigenetic processes provide a critical link between environmental insults to the …
sequence. Epigenetic processes provide a critical link between environmental insults to the …
Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma
EE Thompson, Q Dang, B Mitchell-Handley… - Genome Medicine, 2020 - Springer
Background A challenge in the post-GWAS era is to assign function to disease-associated
variants. However, available resources do not include all tissues or environmental …
variants. However, available resources do not include all tissues or environmental …