Insights on molecular mechanisms of chondrocytes death in osteoarthritis

E Charlier, B Relic, C Deroyer, O Malaise… - International journal of …, 2016 - mdpi.com
Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation.
Medical care is mainly based on alleviating pain symptoms. Compelling studies report the …

The role of oxidative stress in the development of knee osteoarthritis: A comprehensive research review

L Liu, P Luo, M Yang, J Wang, W Hou… - Frontiers in molecular …, 2022 - frontiersin.org
Knee osteoarthritis (KOA) is one of the most common degenerative diseases, and its core
feature is the degeneration and damage of articular cartilage. The cartilage degeneration of …

Anti‐Inflammatory Effects of Flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT‐1 and NF‐κB Activations, Whereas Flavone, Isorhamnetin, Naringenin …

M Hämäläinen, R Nieminen, P Vuorela… - Mediators of …, 2007 - Wiley Online Library
In inflammation, bacterial products and proinflammatory cytokines induce the formation of
large amounts of nitric oxide (NO) by inducible nitric oxide synthase (iNOS), and compounds …

[PDF][PDF] Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets

JP Pelletier, J Martel‐Pelletier… - Arthritis & Rheumatism …, 2001 - stem-art.com
Osteoarthritis (OA) is a well-known disease that is part of the aging process and also one of
the most common diseases among mammals. Although this musculoskeletal disorder has …

Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds

DJ Son, JW Lee, YH Lee, HS Song, CK Lee… - Pharmacology & …, 2007 - Elsevier
Bee venom (BV) therapy (BVT), the therapeutic application of BV, has been used in
traditional medicine to treat diseases, such as arthritis, rheumatism, pain, cancerous tumors …

Role of iNOS in osteoarthritis: Pathological and therapeutic aspects

N Ahmad, MY Ansari, TM Haqqi - Journal of cellular physiology, 2020 - Wiley Online Library
Accumulating evidence suggests that inflammation has a key role in the pathogenesis of
osteoarthritis (OA). Nitric oxide (NO) has been established as one of the major inflammatory …

[HTML][HTML] Osteophytes: relevance and biology

PM Van Der Kraan, WB Van Den Berg - Osteoarthritis and cartilage, 2007 - Elsevier
OBJECTIVE: Osteophytes are common features of osteoarthritis. This review summarizes
the current understanding of the clinical relevance and biology of osteophytes. METHOD …

[HTML][HTML] Oxygen and reactive oxygen species in cartilage degradation: friends or foes?

Y Henrotin, B Kurz, T Aigner - Osteoarthritis and cartilage, 2005 - Elsevier
OBJECTIVES: This review is focused on the influence of oxygen and derived reactive
species on chondrocytes aging, metabolic function and chondrogenic phenotype …

Post-traumatic osteoarthritis: from mouse models to clinical trials

CB Little, DJ Hunter - Nature Reviews Rheumatology, 2013 - nature.com
Osteoarthritis (OA), the most common of all arthropathies, is a leading cause of disability and
has a large (and growing) worldwide socioeconomic cost. Despite its burgeoning …

The role of biomechanics and inflammation in cartilage injury and repair

F Guilak, B Fermor, FJ Keefe, VB Kraus… - Clinical Orthopaedics …, 2004 - journals.lww.com
Osteoarthritis is a painful and debilitating disease characterized by progressive
degenerative changes in the articular cartilage and other joint tissues. Biomechanical factors …