The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
Y Shiloh, Y Ziv - Nature reviews Molecular cell biology, 2013 - nature.com
The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an
apical activator of the DNA damage response in the face of DNA double-strand breaks …
apical activator of the DNA damage response in the face of DNA double-strand breaks …
Multiple functions of BCL-2 family proteins
JM Hardwick, L Soane - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This
family of interacting partners includes inhibitors and inducers of cell death. Together they …
family of interacting partners includes inhibitors and inducers of cell death. Together they …
Apaf-1: Regulation and function in cell death
Apoptosis, a form of programmed cell death, is responsible for eliminating damaged or
unnecessary cells in multicellular organisms. Various types of intracellular stress trigger …
unnecessary cells in multicellular organisms. Various types of intracellular stress trigger …
Mechanisms of ATM activation
TT Paull - Annual review of biochemistry, 2015 - annualreviews.org
The ataxia-telangiectasia mutated (ATM) protein kinase is a master regulator of the DNA
damage response, and it coordinates checkpoint activation, DNA repair, and metabolic …
damage response, and it coordinates checkpoint activation, DNA repair, and metabolic …
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography
LH Thompson - Mutation Research/Reviews in Mutation Research, 2012 - Elsevier
The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
Common mechanisms of PIKK regulation
CA Lovejoy, D Cortez - DNA repair, 2009 - Elsevier
Kinases in the phosphoinositide three-kinase-related kinase (PIKK) family include ATM
(ataxia-telangiectasia mutated), ATR (ATM-and Rad3-related), DNA-PKcs (DNA-dependent …
(ataxia-telangiectasia mutated), ATR (ATM-and Rad3-related), DNA-PKcs (DNA-dependent …
DNA damage response in cisplatin-induced nephrotoxicity
Cisplatin and its derivatives are widely used chemotherapeutic drugs for cancer treatment.
However, they have debilitating side effects in normal tissues and induce ototoxicity …
However, they have debilitating side effects in normal tissues and induce ototoxicity …
A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer
MicroRNAs (miRNAs) are small noncoding RNAs that direct gene regulation through
translational repression and degradation of complementary mRNA. Although miRNAs have …
translational repression and degradation of complementary mRNA. Although miRNAs have …
ATM activation and signaling under hypoxic conditions
Z Bencokova, MR Kaufmann, IM Pires… - … and cellular biology, 2009 - Am Soc Microbiol
The ATM kinase has previously been shown to respond to the DNA damage induced by
reoxygenation following hypoxia by initiating a Chk 2-dependent cell cycle arrest in the G 2 …
reoxygenation following hypoxia by initiating a Chk 2-dependent cell cycle arrest in the G 2 …
ATM protein kinase: the linchpin of cellular defenses to stress
ATM is the most significant molecule involved in monitoring the genomic integrity of the cell.
Any damage done to DNA relentlessly challenges the cellular machinery involved in …
Any damage done to DNA relentlessly challenges the cellular machinery involved in …