Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …

Protein tyrosine phosphatases (PTPs) are enzymes that remove phosphate from tyrosine
residues in proteins. Recent whole-exome sequencing of human cancer genomes reveals …

Protein tyrosine phosphatase receptor type J (PTPRJ), also known as DEP-1, HPTPη, or
CD148, belongs to the R3 subfamily of receptor protein tyrosine phosphatases (RPTPs). It …

Whole exome sequencing was used to investigate the genetic cause of mitochondrial
disease in two siblings with a syndrome of congenital lamellar cataracts associated with …

DEP-1/PTPRJ is a receptor-like protein tyrosine phosphatase mainly known for its
antiproliferative and tumor-suppressive functions. Many identified substrates are growth …

Cytogenetic analysis is essential for the diagnosis and prognosis of hematopoietic
neoplasms in current clinical practice. Many hematopoietic malignancies are characterized …

Protein tyrosine phosphatases, together with protein tyrosine kinases, control many
molecular signaling steps that control life at cellular and organismal levels. Impairing …

Background: Renal cell carcinoma (RCC) is a common urological cancer, and its risk
correlates with environmental factors such as obesity, smoking and hypertension. Microarray …

Protein tyrosine phosphatase receptor type J (PTPRJ, DEP1) is a tumour suppressor gene
that negatively regulates such processes as angiogenesis, cell proliferation and migration …

Simple Summary Lynch syndrome is a hereditary cancer condition caused by a pathogenic
variant (mutation) within one of the mismatch repair (MMR) genes. Risks for cancer vary by …