Cardiovascular complications of down syndrome: scoping review and expert consensus
K Dimopoulos, A Constantine, P Clift, R Condliffe… - Circulation, 2023 - Am Heart Assoc
Cardiovascular disease is a leading cause of morbidity and mortality in individuals with
Down syndrome. Congenital heart disease is the most common cardiovascular condition in …
Down syndrome. Congenital heart disease is the most common cardiovascular condition in …
Down syndrome and autoimmune disease
Down syndrome is the most common genetic cause of intellectual disability and has
previously been associated with a variety of autoimmune disorders affecting multiple organ …
previously been associated with a variety of autoimmune disorders affecting multiple organ …
Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model
Down syndrome (DS), the genetic condition caused by trisomy 21, is characterized by
variable cognitive impairment, immune dysregulation, dysmorphogenesis and increased …
variable cognitive impairment, immune dysregulation, dysmorphogenesis and increased …
Multidimensional definition of the interferonopathy of Down syndrome and its response to JAK inhibition
Individuals with Down syndrome (DS) display chronic hyperactivation of interferon signaling.
However, the clinical impacts of interferon hyperactivity in DS are ill-defined. Here, we …
However, the clinical impacts of interferon hyperactivity in DS are ill-defined. Here, we …
Variegated overexpression of chromosome 21 genes reveals molecular and immune subtypes of Down syndrome
MG Donovan, NP Eduthan, KP Smith, EC Britton… - Nature …, 2024 - nature.com
Individuals with Down syndrome, the genetic condition caused by trisomy 21, exhibit strong
inter-individual variability in terms of developmental phenotypes and diagnosis of co …
inter-individual variability in terms of developmental phenotypes and diagnosis of co …
[HTML][HTML] IGF1 deficiency integrates stunted growth and neurodegeneration in Down syndrome
Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), is characterized by
stunted growth, cognitive impairment, and increased risk of diverse neurological conditions …
stunted growth, cognitive impairment, and increased risk of diverse neurological conditions …
Unraveling Down syndrome: from genetic anomaly to artificial intelligence-enhanced diagnosis
Down syndrome arises from chromosomal non-disjunction during gametogenesis, resulting
in an additional chromosome. This anomaly presents with intellectual impairment, growth …
in an additional chromosome. This anomaly presents with intellectual impairment, growth …
Cardiometabolic profiles in children and adults with overweight and obesity and down syndrome
NM Oreskovic, NT Baumer, C Di Camillo… - American Journal of …, 2023 - Wiley Online Library
Individuals with Down syndrome (DS) are at increased risk for being overweight/obese, but
the associated cardiometabolic risk (CR) is not clear. Cross‐sectional anthropometric and …
the associated cardiometabolic risk (CR) is not clear. Cross‐sectional anthropometric and …
Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome
Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), is characterized by
delayed neurodevelopment, accelerated aging, and increased risk of many co-occurring …
delayed neurodevelopment, accelerated aging, and increased risk of many co-occurring …
[HTML][HTML] Prevalence of mental health conditions among 6078 individuals with Down syndrome in the United States
A Rivelli, V Fitzpatrick, S Chaudhari… - Journal of Patient …, 2022 - ncbi.nlm.nih.gov
Findings from a recent study of the largest documented cohort of individuals with Down
syndrome (DS) in the United States described prevalence of common disease conditions …
syndrome (DS) in the United States described prevalence of common disease conditions …