Impact of environmental factors on stilbene biosynthesis

A Valletta, LM Iozia, F Leonelli - Plants, 2021 - mdpi.com
Stilbenes are a small family of polyphenolic secondary metabolites that can be found in
several distantly related plant species. These compounds act as phytoalexins, playing a …

Synthetic biology of plant natural products: From pathway elucidation to engineered biosynthesis in plant cells

X Zhu, X Liu, T Liu, Y Wang, N Ahmed, Z Li… - Plant Communications, 2021 - cell.com
Plant natural products (PNPs) are the main sources of drugs, food additives, and new
biofuels and have become a hotspot in synthetic biology. In the past two decades, the …

Phytostilbenes as agrochemicals: Biosynthesis, bioactivity, metabolic engineering and biotechnology

P Jeandet, A Vannozzi, E Sobarzo-Sánchez… - Natural product …, 2021 - pubs.rsc.org
Covering: 1976 to 2020. Although constituting a limited chemical family, phytostilbenes
represent an emblematic group of molecules among natural compounds. Ever since their …

Next-generation metabolic engineering approaches towards development of plant cell suspension cultures as specialized metabolite producing biofactories

SS Arya, JE Rookes, DM Cahill, SK Lenka - Biotechnology Advances, 2020 - Elsevier
Plant cell suspension culture (PCSC) has emerged as a viable technology to produce plant
specialized metabolites (PSM). While Taxol® and ginsenoside are two examples of …

Resveratrol and cyclodextrins, an easy alliance: Applications in nanomedicine, green chemistry and biotechnology

P Jeandet, E Sobarzo-Sánchez, MS Uddin, R Bru… - Biotechnology …, 2021 - Elsevier
Most drugs or the natural substances reputed to display some biological activity are
hydrophobic molecules that demonstrate low bioavailability regardless of their mode of …

Whole-cell biocatalytic, enzymatic and green chemistry methods for the production of resveratrol and its derivatives

P Jeandet, E Sobarzo-Sánchez, AS Silva… - Biotechnology …, 2020 - Elsevier
Resveratrol and the biosynthetically related stilbenes are plant secondary metabolites with
diverse pharmacological effects. The versatile functions of these compounds in plant …

Engineering stilbene metabolic pathways in microbial cells

P Jeandet, E Sobarzo-Sánchez, C Clément… - Biotechnology …, 2018 - Elsevier
Numerous in vitro and in vivo studies on biological activities of phytostilbenes have brought
to the fore the remarkable properties of these compounds and their derivatives, making them …

E-Stilbenes: General Chemical and Biological Aspects, Potential Pharmacological Activity Based on the Nrf2 Pathway

ELSS Mendonça, JA Xavier, MBT Fragoso, MO Silva… - Pharmaceuticals, 2024 - mdpi.com
Stilbenes are phytoalexins, and their biosynthesis can occur through a natural route
(shikimate precursor) or an alternative route (in microorganism cultures). The latter is a …

Rational design of resveratrol O-methyltransferase for the production of pinostilbene

DP Herrera, AM Chánique… - International Journal of …, 2021 - mdpi.com
Pinostilbene is a monomethyl ether analog of the well-known nutraceutical resveratrol. Both
compounds have health-promoting properties, but the latter undergoes rapid metabolization …

Antioxidant activity and nano delivery of the most frequently applied stilbene derivates: a brief and recent review

S Choiri, R Fitriastuti, FZ Faradiva… - Pharmaceutical …, 2021 - ps.tbzmed.ac.ir
As of recent, the appearance rate of several degenerative diseases and cancer influenced
by oxidative stress continues to increase dramatically. Many compounds with high potential …