Metabolites are intermediate products of cellular metabolism catalysed by various enzymes.
Metabolic remodelling, as a biochemical fingerprint of cancer cells, causes abnormal …

In eukaryotes, end-binding (EB) proteins serve as a hub for orchestrating microtubule
dynamics and are essential for cellular dynamics and organelle movements. EB proteins …

Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …

A generalizable strategy with programmable site specificity for in situ profiling of histone
modifications on unperturbed chromatin remains highly desirable but challenging. We …

BACKGROUND: Cardiac hypertrophy and its associated remodeling are among the leading
causes of heart failure. Lysine crotonylation is a recently discovered posttranslational …

Vitamin C (L-ascorbic acid) is an essential nutrient for human health, and its deficiency has
long been known to cause scurvy. Sodium-dependent vitamin C transporters (SVCTs) are …

Histone post-translational modifications (HPTMs), as one of the core mechanisms of
epigenetic regulation, are garnering increasing attention due to their close association with …

Protein-modifying enzymes regulate the dynamics of myriad post-translational modification
(PTM) substrates. Precise characterization of enzyme-substrate associations is essential for …

Histone lysine crotonylation was first identified as a new type of post-translational
modification in 2011. In recent years, prominent progress has been made in the study of …

Faithful chromosome segregation of 8 duplicated haploid genomes into 8 daughter gametes
is essential for male gametogenesis and mosquito transmission of Plasmodium …