Lysosomes are the main proteolytic compartments of mammalian cells comprising of a
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …

Maintenance of plasma membrane integrity is essential for normal cell viability and function.
Thus, robust membrane repair mechanisms have evolved to counteract the eminent threat of …

The ability of the brain to store and process information relies on changing the strength of
connections between neurons. Synaptic facilitation is a form of short-term plasticity that …

During an action potential, Ca 2+ entering a presynaptic terminal triggers synaptic vesicle
exocytosis and neurotransmitter release in less than a millisecond. How does Ca 2+ …

Eukaryotic cells have been confronted throughout their evolution with potentially lethal
plasma membrane injuries, including those caused by osmotic stress, by infection from …

It has been known for more than 70 years that synaptic strength is dynamically regulated in a
use-dependent manner. At synapses with a low initial release probability, closely spaced …

Membrane fusion can occur between cells, between different intracellular compartments,
between intracellular compartments and the plasma membrane and between lipid-bound …

The auditory inner hair cell (IHC) ribbon synapse operates with an exceptional temporal
precision and maintains a high level of neurotransmitter release. However, the molecular …

In forebrain neurons, knockout of synaptotagmin-1 blocks fast Ca 2+-triggered synchronous
neurotransmitter release but enables manifestation of slow Ca 2+-triggered asynchronous …

Rapid plasma membrane resealing is essential for cellular survival. Earlier studies showed
that plasma membrane repair requires Ca2+-dependent exocytosis of lysosomes and a …