Spinal cord injury (SCI) is a destructive neurological and pathological state that causes
major motor, sensory and autonomic dysfunctions. Its pathophysiology comprises acute and …

The interaction between microglia and astrocytes significantly influences neuroinflammation.
Microglia/astrocytes, part of the neurovascular unit (NVU), are activated by various brain …

Neuroinflammation in the central nervous system (CNS) is an important subject of
neuroimmunological research. Emerging evidence suggests that neuroinflammation is a key …

The CNS is prone to heterogeneous insults of diverse etiologies that elicit multifaceted
responses. Acute and focal injuries trigger wound repair with tissue replacement. Diffuse …

Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

Axonal regeneration and formation of tripartite (axo-glial) junctions at damaged sites is a
prerequisite for early repair of injured spinal cord. Transplantation of stem cells at such sites …

Inflammatory activation of microglia is a hallmark of several disorders of the central nervous
system. In addition to protecting the brain against inflammatory insults, microglia are …

Microglia are highly dynamic immune cells of the CNS and their dynamism is proposed to be
regulated by neuronal activities. However, the mechanisms underlying neuronal regulation …

It is widely accepted that glutamate-mediated neuronal hyperexcitation plays a causative
role in eliciting seizures. Among glutamate receptors, the roles of N-methyl-D-aspartate …

Microglia are critical nervous system-specific cells influencing brain development,
maintenance of the neural environment, response to injury, and repair. They contribute to …