Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically
associated with abnormal vasculature, which results in a reduced supply of oxygen and …

The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer,
but new platinum agents have been very slow to enter the clinic. Recently, however, there …

Since the discovery by Rosenberg and collaborators of the antitumor activity of cisplatin 35
years ago, three platinum antitumor drugs (cisplatin, carboplatin and oxaliplatin) have …

Introduction Chemotherapy‐induced neuropathies are one of the most common side effects
of cancer treatment, surpassing bone marrow suppression and kidney dysfunction …

Journal of Clinical Oncology recently featured the dramatic changes that took place within
the last 50 years resulting in transforming malignant germ cell testicular tumors from highly …

This article reviews the chemical and antitumoral properties of thiosemicarbazone complex-
based drugs containing platinum (II) or palladium (II). Tetranuclear orthometallated …

The efficacy of cisplatin in cancer chemotherapy is limited by the development of resistance.
Although the molecular mechanisms involved in chemoresistance are poorly understood …

Transitional metals have a large variety of coordination numbers and geometries, accessible
redox states in physiological conditions and a wide range of thermodynamic and reactivity …

Background: Because cancer is a complex disease, it is unlikely that a single mono
functional 'targeted'drug will be effective for treating this most advanced disease. Combined …

Cisplatin and carboplatin have dominated the drug therapy of ovarian cancer and other
gynecologic malignancies during the past three decades. This review, based on a recent …