Extracellular vesicles and nanoparticles: emerging complexities

DK Jeppesen, Q Zhang, JL Franklin, RJ Coffey - Trends in Cell Biology, 2023 - cell.com
The study of extracellular vesicles (EVs) and nanoparticles (NPs) is rapidly expanding
because recent discoveries have revealed a much greater complexity and diversity than was …

Comprehensive isolation of extracellular vesicles and nanoparticles

Q Zhang, DK Jeppesen, JN Higginbotham… - Nature protocols, 2023 - nature.com
There is an increasing appreciation for the heterogeneous nature of extracellular vesicles
(EVs). In addition, two nonvesicular extracellular nanoparticles (NVEPs), exomeres and …

exRNA-eCLIP intersection analysis reveals a map of extracellular RNA binding proteins and associated RNAs across major human biofluids and carriers

EL LaPlante, A Stürchler, R Fullem, D Chen… - Cell Genomics, 2023 - cell.com
Although the role of RNA binding proteins (RBPs) in extracellular RNA (exRNA) biology is
well established, their exRNA cargo and distribution across biofluids are largely unknown …

Landscape of exosomes to modified exosomes: a state of the art in cancer therapy

D Mirgh, S Sonar, S Ghosh, MD Adhikari… - RSC …, 2024 - pubs.rsc.org
Exosomes are a subpopulation of extracellular vesicles (EVs) that naturally originate from
endosomes. They play a significant role in cellular communication. Tumor-secreted …

Endocytosis blocks the vesicular secretion of exosome marker proteins

Y Ai, C Guo, M Garcia-Contreras, LS Sánchez B… - Science …, 2024 - science.org
Exosomes are secreted vesicles of~ 30 to 150 nm diameter that play important roles in
human health and disease. To better understand how cells release these vesicles, we …

Molecular hallmarks of ageing in amyotrophic lateral sclerosis

CJ Jagaraj, S Shadfar, SA Kashani… - Cellular and Molecular …, 2024 - Springer
Amyotrophic lateral sclerosis (ALS) is a fatal, severely debilitating and rapidly progressing
disorder affecting motor neurons in the brain, brainstem, and spinal cord. Unfortunately …

Non-vesicular extracellular RNA: A potential drug target to intervene cell-cell communication

T Tomita - Pharmacology & Therapeutics, 2024 - Elsevier
The importance of non-vesicular extracellular RNA in the mammalian system is becoming
increasingly apparent. Non-vesicular extracellular RNA is defined as RNA molecules not …

The NanoFlow Repository

JE Arce, JA Welsh, S Cook, J Tigges, I Ghiran… - …, 2023 - academic.oup.com
Abstract Motivation Extracellular particles (EPs) are the focus of a rapidly growing area of
exploration due to the widespread interest in understanding their roles in health and …

Answering open questions in biology using spatial genomics and structured methods

SG Jena, A Verma, BE Engelhardt - BMC bioinformatics, 2024 - Springer
Genomics methods have uncovered patterns in a range of biological systems, but obscure
important aspects of cell behavior: the shapes, relative locations, movement, and …

[HTML][HTML] Emerging connections between GPI-anchored proteins and their extracellular carriers in colorectal cancer

OS Tutanov, SE Glass, RJ Coffey - Extracellular vesicles and …, 2023 - ncbi.nlm.nih.gov
Although extracellular vesicles (EVs) were discovered over 40 years ago, there has been a
resurgence of interest in secreted vesicles and their attendant cargo as novel modes of …