Genetic impacts on DNA methylation: research findings and future perspectives
S Villicaña, JT Bell - Genome biology, 2021 - Springer
Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
DNA methylation and healthy human aging
The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …
include senescence, telomere shortening, and changes in gene expression. Epigenetic …
Pig genome functional annotation enhances the biological interpretation of complex traits and human disease
The functional annotation of livestock genomes is crucial for understanding the molecular
mechanisms that underpin complex traits of economic importance, adaptive evolution and …
mechanisms that underpin complex traits of economic importance, adaptive evolution and …
SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions
We report a new class of artifacts in DNA methylation measurements from Illumina
HumanMethylation450 and MethylationEPIC arrays. These artifacts reflect failed …
HumanMethylation450 and MethylationEPIC arrays. These artifacts reflect failed …
Systematic identification of genetic influences on methylation across the human life course
Background The influence of genetic variation on complex diseases is potentially mediated
through a range of highly dynamic epigenetic processes exhibiting temporal variation during …
through a range of highly dynamic epigenetic processes exhibiting temporal variation during …
Tissue source determines the differentiation potentials of mesenchymal stem cells: a comparative study of human mesenchymal stem cells from bone marrow and …
Abstract Background Mesenchymal stem cells (MSCs) possess intrinsic regeneration
capacity as part of the repair process in response to injury, such as fracture or other tissue …
capacity as part of the repair process in response to injury, such as fracture or other tissue …
A DNA methylation biomarker of alcohol consumption
The lack of reliable measures of alcohol intake is a major obstacle to the diagnosis and
treatment of alcohol-related diseases. Epigenetic modifications such as DNA methylation …
treatment of alcohol-related diseases. Epigenetic modifications such as DNA methylation …
Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control …
JC Chambers, M Loh, B Lehne, A Drong… - The lancet Diabetes & …, 2015 - thelancet.com
Summary Background Indian Asians, who make up a quarter of the world's population, are
at high risk of developing type 2 diabetes. We investigated whether DNA methylation is …
at high risk of developing type 2 diabetes. We investigated whether DNA methylation is …
An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation
Background Schizophrenia is a highly heritable, neuropsychiatric disorder characterized by
episodic psychosis and altered cognitive function. Despite success in identifying genetic …
episodic psychosis and altered cognitive function. Despite success in identifying genetic …
A Bayesian framework for multiple trait colocalization from summary association statistics
Motivation Most genetic variants implicated in complex diseases by genome-wide
association studies (GWAS) are non-coding, making it challenging to understand the …
association studies (GWAS) are non-coding, making it challenging to understand the …