Matrix metalloproteinases (MMPs) have been implicated in several diseases of the nervous
system. Here we review the evidence that supports this idea and discuss the possible …

Over the past decade, new insights have been obtained into the cellular strategies and
molecular mechanisms that guide axons to their targets in the developing vertebrate …

Development of the Nervous System presents a broad and basic treatment of the
established and evolving principles of neural development as exemplified by key …

Two approaches-molecular cloning and immunochemical analysis-have identified one of
the components of Alzheimer's disease amyloid deposits as the serine protease inhibitor α 1 …

Plasminogen activators are important mediators of extracellular metabolism. In the nervous
system, plasminogen activators are thought to be involved in the remodeling events required …

Injury to a peripheral nerve is followed by a remodeling process consisting of axonal
degeneration and regeneration. It is not known how Schwann cell–derived basement …

The cerebellar cortex is implicated in the learning of complex motor skills. This learning may
require synaptic remodeling of Purkinje cell inputs. An extracellular serine protease, tissue …

Although conventionally associated with fibrin clot degradation, recent work has uncovered
new functions for the tissue plasminogen activator (tPA)/plasminogen cascade in central …

We investigated the role of matrix metalloproteinases (MMPs) in acute spinal cord injury
(SCI). Transcripts encoding 22 of the 23 known mammalian MMPs were measured in the …

Matrix metalloproteases (MMPs) and tissue inhibitors of metalloproteases (TIMPs) are
involved in many cell migration phenomena and produced by many cell types, including …